‘Blink’ and you won’t miss amyloids

‘Blink’ and you won’t miss amyloids

Tiny protein structures called amyloids are key to understanding certain devastating age-related diseases, but they are so minuscule they can’t be seen using conventional microscopic methods. A team of engineers at Washington University in St. Louis has developed a new technique that uses temporary fluorescence, causing the amyloids to flash or “blink”, allowing researchers to better spot these problematic proteins.
In sync: How cells make connections could impact circadian rhythm

In sync: How cells make connections could impact circadian rhythm

If you’ve ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism. Every cell in the body has a circadian clock, but until now, researchers were unclear about how networks of cells connect with each other over time. Researchers at Washington University in St. Louis and collaborating institutions have developed a new method that sheds light on these circadian rhythm networks.
Role of cell group behavior target of $1.9 million award

Role of cell group behavior target of $1.9 million award

Amit Pathak, a mechanical engineer at Washington University in St. Louis who specializes in mechanobiology, plans to take a closer look at various aspects of cell group behavior — and their implications for diseases such as cancer — with a prestigious five-year, $1.9 million grant for early-stage investigators from the National Institutes of Health (NIH).
New imaging technique to use bioinspired camera to study tendon, ligament damage

New imaging technique to use bioinspired camera to study tendon, ligament damage

Tommy John surgery, or reconstruction of the ulnar collateral ligament (UCL) in the elbow, has been dubbed an epidemic among Major League Baseball pitchers. A mechanical engineer at Washington University in St. Louis plans to develop a bioinspired imaging technique to study how damage accumulates in the UCL during loading, or the stress of activating the ligament. This could provide insight into what is progressively happening to these soft tissues when pitchers throw fastballs dozens of times during a game.
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