Exercise and similar lifestyle changes may help HIV-positive people avoid metabolic and cardiovascular problems associated with HIV and anti-HIV drugs, School of Medicine researchers are investigating.
The researchers are also studying a new drug therapy and are recruiting volunteers for two clinical trials to test the benefits of exercise and the investigational drug.
Many HIV-positive patients develop diabetes, dyslipidemia, obesity and other metabolic changes that increase cardiovascular disease risk. Led by Kevin E. Yarasheski, Ph.D., associate professor of medicine and of cell biology and physiology, the researchers are testing interventions designed to reduce these metabolic and cardiovascular problems.
“Medical therapy has dramatically improved survival and quality of life for HIV-positive people, but they are living longer and developing traditional cardiovascular disease risk factors,” Yarasheski said. “We don’t know why, but HIV-positive people are developing insulin resistance, high blood cholesterol, abdominal adiposity and high blood pressure at an alarming rate, so we’re looking for safe, effective therapies.
“Established therapies, like exercise and diabetes medications, work well in HIV-negative people, but they need to be tested in HIV-positive people,” Yarasheski said. “Other therapies, like yoga, are novel alternative approaches that complement the standard-of-care for HIV, but very little empirical evidence exists to support those approaches.”
Yarasheski has studied metabolic syndromes in HIV-positive people for more than 10 years, attempting to discover the underlying biologic impairments in muscle and fat tissue metabolism that cause these syndromes, which are linked to HIV infection and to anti-HIV drugs, and to identify effective treatments.
Yarasheski and his colleagues at Living By Design in St. Louis are investigating whether a four-month yoga lifestyle intervention program might help alleviate HIV-related metabolic syndromes and reduce cardiovascular disease risk.
The ancient practice of a Hatha/Ashtanga yoga lifestyle has regained popularity as a complementary therapy for metabolic, body composition and cardiovascular problems because it provides integrated control of eating habits, exercise, rest, breathing style and the mind. Through a focus on postures and controlled breathing, yoga is meant to establish a balance among physiological processes.
In this study, volunteers are assigned to a four-month yoga program, taught by certified instructors, or to no yoga, to see if their metabolic, cardiovascular and quality-of-life profiles improve.
Volunteers will receive nutrition counseling and assessments of metabolism, body composition and cardiovascular function. All screening tests and research-related procedures for these studies are free.
Participants also receive either a supervised gym membership or membership in the yoga program, compensation for their time and effort and travel sup-port to and from appointments and workouts.
For more information, call 747-1090 or 747-1982.