New model will open immune cell’s secrets

Five decades after the discovery of a rare but potentially pivotal immune cell, scientists at Washington University School of Medicine in St. Louis have found a way to eliminate it in mice. The finding, which appears in the journal Immunity, will enable more detailed investigations of the important roles the plasmacytoid dendritic cell (pDC) plays in fighting viruses and causing autoimmune diseases like psoriasis and lupus.

PSA test better predicts cancer in men taking prostate-shrinking drug

A new study by Gerald Andriole, MD, chief of urologic surgery at Washington University School of Medicine in St. Louis, suggests the PSA test is more reliable in men taking dutasteride (Avodart®), a drug widely prescribed to shrink an enlarged prostate gland. Even a slight rise in PSA levels among men taking the drug was a stronger indicator of cancer than rising PSA levels in men taking a dummy pill.

Emerson, AT&T give $7.5 million to Siteman Cancer Center

Innovative, high-priority research initiatives by Washington University scientists at the Alvin J. Siteman Cancer Center are now under way thanks to a $7.5 million grant from Emerson and AT&T. Emerson’s Charitable Trust and the AT&T Foundation are contributing $5 million and $2.5 million, respectively. This commitment will generate an additional $15 million for these initiatives through matching support from Washington University School of Medicine, BJC HealthCare and the Siteman Cancer Center.

MRI scans reveal brain changes in people at genetic risk for Alzheimer’s

People with a known, high risk for Alzheimer’s disease develop abnormal brain function even before the appearance of telltale, amyloid plaques that are characteristic of Alzheimer’s disease, according to a new study from researchers at Washington University School of Medicine in St. Louis. The findings suggest that a gene variant affects brain function long before the brain begins accumulating the amyloid that will eventually lead to dementia. 

Alzheimer’s patients can’t effectively clear sticky plaque component

Neurologists finally have an answer to one of the most important questions about Alzheimer’s disease: Do rising brain levels of a plaque-forming substance mean patients are making more of it or that they can no longer clear it from their brains as effectively? A new study by Randall Bateman, MD, assistant professor of neurology, shows clearance is impaired in Alzheimer’s patients.
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