Medicine & Health

Photo courtesy of National Eye Institute, National Institutes of HealthVisual perception changes as eyes age.Graphic design can be a matter of life and death. Literally. According to the Journal of the American Medical Association, more than 40 percent of Americans aged 65 and over use five or more different medications each week, making unintended drug interactions a major contributor to an estimated annual 180,000 fatal or life-threatening adverse drug reactions. Yet drug labeling is a kind of typographical Wild West, says Ken Botnick, professor of visual communications in the School of Art at Washington University in St. Louis. “Drug companies are required to divulge certain types of information but there are no requirements in terms of how accessible that information is made,” Botnick explains. “Typically, decisions about the way information is organized — the hierarchy of presentation, the size and clarity of type — are simply afterthoughts.” Medical information design is just one of the issues to be explored as part of “Visual Design for an Aging Population,” a national symposium Botnick is organizing in March 2004.

Photo by David Kilper/WUSTL PhotoWendy F. Auslander, Ph.D. (left), works with St. Louis-area peer counselors in the “Eat Well, Live Well” program she pioneered with colleagues at the School of Medicine.As the cases of type 2 diabetes in African-American women increase at an epidemic rate, researchers are examining risk factors involved with this disease in order to create programs that will hopefully slow this growing problem. According to a recent study at the George Warren Brown (GWB) School of Social Work at Washington University in St. Louis, African-American women at risk for type 2 diabetes experience long periods of depression due, in part, to a lack of economic and social resources. “At the beginning of our study, 40 percent of our sample of African-American women at risk for type 2 diabetes reported clinically significant depression,” says Wendy Auslander, Ph.D., professor at GWB and co-author of the study. “Unlike their nondepressed peers, these women reported fewer economic assets and greater economic distress. Issues such as unemployment, low self-esteem and a low appraisal of their economic situation contributed to their depression.”

Chest x-ray of a lung affected by pneumoniaMany medical advances involve complicated new technologies or procedures. But Linda Mundy, M.D., associate professor of medicine and an infectious diseases specialist at Washington University School of Medicine in St. Louis, recently reported good results with a new pneumonia treatment that can be summed up in a single sentence: Get patients up out of bed earlier and more often, and they check out of the hospital an average of one day sooner. Mundy says the high volume of U.S. pneumonia hospitalizations could make the new treatment a potent cost-saver, but added that a second study of the approach, known as early mobilization, is needed to confirm the beneficial effects.

Image courtesy of William C. Chapman, M.D.William Chapman monitors his surgical instrument’s position on corresponding CT scans during liver surgery.Despite being the largest vital organ in the body, the liver has very few identifiable landmarks to help guide a cancer surgeon around its surface. Two-dimensional ultrasound images currently are the standard navigational tool, making it difficult to discern depth and location in the liver during surgery to remove tumors. That’s why a research team led by William C. Chapman, M.D., professor of surgery and chief of the Abdominal Transplantation Section at Washington University School of Medicine in St. Louis plans to launch trials examining the use of three-dimensional imaging techniques to complement ultrasound during liver surgery. The research team will investigate standard three-dimensional imaging techniques like MRI, CT scanning and PET for guiding surgeons during tumor removal surgery.

The mind and the body are intimately linked, but although more and more research is demonstrating that the mind plays a role in sickness and in health, little is understood about how a person’s mental health affects physical health. A Washington University team of investigators led by Ray E. Clouse, M.D, professor of medicine and psychiatry, and Patrick J. Lustman, Ph.D., professor of psychiatry, hopes to change that by launching a new Center for Mind/Body Research that will focus specifically on ways that mental health affects heart disease, diabetes, cancer and other illnesses. New research has shown, for example, that although women are at a lower risk for heart attacks than men, the risk for women with diabetes and depression is virtually identical to what’s seen in men. The investigators believe that depression is the main cause of that increased risk, but they hope that by focusing more closely on mind/body interactions they will be able to understand more about the relationship between mental health and physical well being.

December/January Medical Science & Health Tip Sheet

Rebecca Dresser, an expert on biomedical research law and bioethics and the Daniel Noyes Kirby Professor of Law at Washington University in St. Louis, discusses the legal and ethical implications of stem cell research with Mike Sampson of KWMU’s “St. Louis on the Air” Nov. 25. Dresser is also a member of the President’s Council on Bioethics. Listen to the program from the KWMU Web site.

Image courtesy of Cindy LustigParts of the brain involved in a “resting network” show large differences between young adults, older adults, and people with Alzheimer’s disease.Researchers tracking the ebb and flow of cognitive function in the human brain have discovered surprising differences in the ability of younger and older adults to shut down a brain network normally active during periods of passive daydreaming. The differences, which are especially pronounced in people with dementia, may provide a clear and powerful new method for diagnosing individuals in the very early stages of Alzheimer’s disease.

Researchers have devised a new hearing test that measures the auditory brainstem response 20 times faster than current methodology.The marvels of mathematics may open the door to a new, improved hearing test for newborns. A mathematician and a recent electrical engineering doctoral graduate from Washington University in St. Louis have devised a hearing test that measures the auditory brainstem response 20 times faster than current methodology. The technique allows for testing on small digital machines that takes just two minutes instead of the hour current methods take, and volunteers instead of medical personnel can administer it. This bodes well for mandatory hearing testing of newborns within three years.

Glucocorticoid receptors on steroids.Doctors have used steroids for decades to control autoimmune and inflammatory diseases such as rheumatoid arthritis, lupus and inflammatory bowel disease, but their potentially serious side effects — including bone loss, obesity, diabetes and growth impairment — have made it difficult to keep patients on the drugs for prolonged periods of time. Endocrinologist Louis Muglia, M.D., Ph.D., associate professor of molecular biology and pharmacology and of pediatrics at Washington University School of Medicine in St. Louis, and colleagues have recently identified a key component of steroids’ effects on the immune system, a possible first step toward developing new drugs that can offer the same benefits as steroids without the many potentially serious side effects.