School of Medicine researchers are seeking volunteers to test an investigational drug for the treatment of complex regional pain syndrome, a chronic nerve disorder that often affects the arms and legs after injuries such as trauma or infection.
Anthony H. Guarino, M.D., instructor of anesthesiology, is joining scientists from around the country to test the drug, called CC-5013.
“These patients can have very severe pain,” Guarino said. “The pain often lingers, and although available drugs can help, some evidence suggests that CC-5013 might have more success regulating this difficult-to-treat pain.”
The drug is also being tested for treatment of various cancers. Researchers think the drug acts by regulating certain chemicals produced in the body that contribute to pain and inflammation following injury.
To be eligible for the study, volunteers must be at least 18 and have had pain from the syndrome for at least one year.
Those who qualify will receive a daily dose of either the study medication or an inactive placebo for 12 weeks.
After 12 weeks, all participants will receive the drug. If the drug helps to control pain, volunteers will be able to remain on the drug and in the study for about a year.
Volunteers will receive free study-related physical exams, laboratory tests and investigational study medication.
They will also be compensated for time and travel.
The study requires visits to the University’s Pain Management Center, located at 969 N. Mason Road.
Patients will have blood samples drawn and receive electrocardiograms at Barnes-Jewish Hospital West County.
For more information, call study coordinator Martha Cornell at 996-8887.