cancer

Tiles painted by cancer patients and their familiesPatients undergoing treatment at the Siteman Cancer Center have a new option to pass the time. They can get creative and paint ceramic tiles for a display in the treatment area. Arts as Healing, a program facilitated by the School of Medicine’s Medical Photography, Illustration and Computer Graphics (MedPIC) department, is currently working on “Your Square Matters,” which allows patients and their families to paint a 4-inch square ceramic tile.

Tiles painted by cancer patients and their familiesPatients undergoing treatment at the Siteman Cancer Center have a new option to pass the time. They can get creative and paint ceramic tiles for a display in the treatment area. Arts as Healing, a program facilitated by the School of Medicine’s Medical Photography, Illustration and Computer Graphics (MedPIC) department, is currently working on “Your Square Matters,” which allows patients and their families to paint a 4-inch square ceramic tile. Already, more than 400 tiles have been completed and are on display in Siteman’s infusion center.

Mice with Tax-induced leukemia/lymphoma develop large tumors and many areas of bone destruction, as shown in this X-ray.Defeating cancerous tumors by attacking healthy cells seems like an unusual strategy, but researchers at the School of Medicine have shown the strategy to be effective against leukemia/lymphoma in mice. The research group found that inhibiting normal bone-maintenance cells called osteoclasts not only prevented the mice’s cancer from spreading to their bones, it also slowed the growth of tumors in the body’s soft tissues.

Mice with Tax-induced leukemia/lymphoma develop large tumors and many areas of bone destruction, as shown in this X-ray.Defeating cancerous tumors by attacking healthy cells seems like an unusual strategy, but researchers at Washington University School of Medicine in St. Louis have shown the strategy to be effective against leukemia/lymphoma in mice. The research group found that inhibiting normal bone-maintenance cells called osteoclasts not only prevented the mice’s cancer from spreading to their bones, it also slowed the growth of tumors in the body’s soft tissues.

Repair proteins (bright green areas) are inhibited from gathering at sites of DNA damage.To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. Now researchers at the School of Medicine have identified a protein with a role in homologous recombination, and the discovery could be exploited as part of a two-pronged treatment strategy to kill cancer cells by eliminating their ability to repair DNA.

Repair proteins (bright green areas) are inhibited from gathering at sites of DNA damage.To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. Now researchers at Washington University School of Medicine in St. Louis have identified a protein with a role in homologous recombination, and the discovery could be exploited as part of a two-pronged treatment strategy to kill cancer cells by eliminating their ability to repair DNA.

Cell phone radiation doesn’t stress human cells.Weighing in on the debate about whether cell phones have adverse health effects, researchers at the School of Medicine have found that the electromagnetic radiation produced by cell phones does not activate the stress response in mouse, hamster or human cells growing in cultures. High levels of the stress response are thought to result in changes associated with malignancy.

Cell phone radiation doesn’t stress human cells.Weighing in on the debate about whether cell phones have adverse health effects, researchers at Washington University School of Medicine in St. Louis have found that the electromagnetic radiation produced by cell phones does not activate the stress response in mouse, hamster or human cells growing in cultures. The stress response is a cellular protection mechanism set into motion by various adverse stimuli, including heat shock, heavy metals, and inflammation. High levels of the stress response in cells are thought to result in changes associated with malignancy.

Genes respond to chemo drugOncologists aren’t sure exactly why patients with the same cancer often respond very differently to the same treatment, but a growing body of evidence suggests the answer lies somewhere in the genes. Now researchers at the School of Medicine have become the first to profile the activity of whole sets of genes involved in processing chemotherapeutic drugs.

A look at the activity of 24 genes in 52 patients as those genes respond to the chemotherapy drug 5-fluorourancilOncologists aren’t sure exactly why patients with the same cancer often respond very differently to the same treatment, but a growing body of evidence suggests the answer lies somewhere in the genes. Now researchers at Washington University School of Medicine in St. Louis have become the first to profile the activity of whole sets of genes involved in processing chemotherapeutic drugs.