brain

Washington University School of Medicine and St. Jude Children’s Research Hospital announced in a Jan. 25 news conference in Washington, D.C., an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers.

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older.

Photo by David KilperLarry A.Taber, Ph.D., (left) the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, employ a microindentation device to measure the mechanical properties of embryonic hearts and brains. The researchers are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and more intellectual capacity) than a brain of comparable volume with a smooth surface.

Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.

David Kilper/WUSTL Photo(L-R) Larry Taber, postdoctoral researcher Gang Xu and Philip Bayly examine brain and heart cells to learn something of the mechanics involved in brain folding.Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Phillip Bayly, Ph.D., Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.

Comparing images of brain activity in response to the “self-remember,” left, and “self-future” event cues, researchers found a surprisingly complete overlap among regions of the brain used.Using brain imaging, researchers from Washington University in St. Louis have identified several brain regions that are involved in the uniquely human ability to envision future events. The study, to be published in the journal PNAS, provides evidence that memory and future thought are highly interrelated and helps explain why future thought may be impossible without memories. Findings suggest that envisioning the future may be a critical prerequisite for many higher-level planning processes.

Photo by David Kilper / WUSTL PhotoResearchers enabled a 14-year-old to play a video game using signals from his brain.Teenage boys and computer games go hand-in-hand. Now, a St. Louis-area teenage boy and a computer game have gone hands-off, thanks to a unique experiment conducted by a team of neurosurgeons, neurologists, and engineers at Washington University in St. Louis. The boy, a 14-year-old who suffers from epilepsy, is the first teenager to play a two-dimensional video game, Space Invaders, using only the signals from his brain to make movements.

Photo by David Kilper / WUSTL PhotoResearchers have enabled a 14-year-old to play a two-dimensional video game using signals from his brain instead of his hands.Teenage boys and computer games go hand-in-hand. Now, a St. Louis-area teenage boy and a computer game have gone hands-off, thanks to a unique experiment conducted by a team of neurosurgeons, neurologists, and engineers at Washington University in St. Louis. The boy, a 14-year-old who suffers from epilepsy, is the first teenager to play a two-dimensional video game, Space Invaders, using only the signals from his brain to make movements. More…

In the Thoroughman laboratory, volunteers play games on a computer screeen using a robotic arm so that Thoroughman and his colleagues can study how people learn motor skills.Central to being human is the ability to adapt: We learn from our mistakes. Previous theories of learning have assumed that the size of learning naturally scales with the size of the mistake. But now biomedical engineers at Washington University in St. Louis have shown that people can use alternative strategies: Learning does not necessarily scale proportionally with error.

Drosophila melanoFor years, two schools of thought have dominated neurobiologists’ theories about how early nerve cells develop specialties that allow the assembly of a mature brain. One theory suggests master regulators trigger the development, while the other attributes the development to interactions between local factors. In a new study of developing fruit fly brain cells, scientists at Washington University School of Medicine and Harvard University showed that both models are valid.