School of Medicine

Lenabell tells the story of a woman with sickle cell disease — including her experimental failures as well as near-miraculous successes.

Faddis and colleagues use a catheter with a magnet at its tip combined with a magnetic guidance system machine to help guide the magnetic catheter as it moves inside the heart.Thanks to advances in cardiology and in magnetic technology, it’s now possible to use magnetic fields to guide tools used to treat certain heart rhythm problems. Cardiologists can treat heart rhythm abnormalities without surgery by using catheters to deliver treatment. Catheters are long, narrow tubes that are run from the groin to the heart via blood vessels using X-ray images for guidance. A team at Washington University School of Medicine in St. Louis has found that the Magnetic Navigation System (MNS) developed by Stereotaxis Inc. allows them to guide catheters within the heart more accurately. Instead of a standard design, MNS catheters contain a magnetic tip. In the same way the needle on a compass aligns itself with the direction of the Earth’s magnetic field, the catheter’s magnetic tip aligns itself with a magnetic field surrounding the patient and allows physicians to more easily guide the catheter in order to locate and treat problem areas in the heart.

Dr. James Lowe in the operating room.Beauty may be in the eye of the beholder, but plastic and reconstructive surgeons at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis are trying to learn the basics of aesthetic beauty in various ethnic groups. When plastic surgeons operate, they don’t want to make African-Americans, Hispanics, Asians, Native Americans and other groups look the same. Rather, they hope to preserve ethnicity while at the same time restoring or enhancing beauty. The Washington University team is one of only a handful worldwide that is scientifically studying ways to preserve ethnicity in plastic surgery procedures, and as more people from different ethnic backgrounds seek plastic surgery, defining aesthetic attractiveness in various ethnic groups is becoming more important.

A protein known as Pgp has pumped an imaging agent that glows away from a tumor on the lower right of this mouse.Oncologists dread the appearance of MDR1 P-glycoprotein (Pgp), a protein found on the surface of drug-resistant cancers that pumps away chemotherapy treatments. Now researchers have discovered Pgp also rids cells of a bioluminescent agent used in imaging research. According to David Piwnica-Worms, M.D., Ph.D., professor of molecular biology and pharmacology and of radiology and director of Washington University’s Molecular Imaging Center, the finding means scientists now have a direct, real-time method for assessing treatments designed to block drug resistance in animal models of cancer because if Pgp is present, the imaging agent is expelled from cells, it’s also likely that those cells will be resistant to chemotherapy. On the other hand, the discovery also means basic researchers, who make frequent use of the luminescent imaging agent (derived from a sea pansy or soft coral), have to make sure that what they are seeing isn’t being affected by interactions with Pgp.

With the graying of America, millions of people across the nation are facing the same tough question: when do older people become unsafe drivers? In one of the first studies to track driving performance in older adults, researchers at Washington University in St. Louis found that over time, driving abilities predictably worsen in individuals with early Alzheimer’s disease and, to a lesser extent, in older adults without dementia. People with mild dementia had the fastest rate of decline, but there also were declines in nondemented study participants. The researchers also found that increased age alone appeared to be a risk factor in driving performance. Because Alzheimer’s disease is progressive and driving performance inevitably does worsen, the challenge is to figure out how to predict and evaluate dangerous declines in driving performance. The researchers suggest that testing individuals with mild dementia every six months might be a useful way to keep unsafe drivers off the roads.

A study that included investigators in the School of Medicine is the first to demonstrate an association between a particular gene and alcoholism. Click here for more medical articles

Study participants with optic nerve disease were 20 times more likely to be pathologically sleepy than those with normal sight. Click here for more medical articles

In some people smoking rewires the brain, producing a powerful addiction that may never be entirely cured, experts say. An estimated 35 million smokers try to kick the habit each year, but only about 7 percent succeed in remaining smoke-free for more than a year. Most relapse within a few days of quitting and require multiple attempts before they can give up cigarettes. “The people who could quit, quit. Now we’re left with a group of really committed smokers,” explains WUSTL geneticist Laura Bierut in a recent St. Louis Post-Dispatch news article.

Little is understood about how depression makes people feel sad, but neuroscientists do know that the brain chemical serotonin is involved. School of Medicine researchers studied 46 people with active depression and compared positron emission tomography (PET) scans of their brains to scans from 29 people who were not depressed. The team was measuring levels of a particular type of serotonin receptor called the 5-HT2A receptor.

Growing up practically next door to the National Institutes of Health, Alexander W. Dromerick, M.D., became fascinated with science at a young age. But it wasn’t long before he realized that the people behind the science are what ultimately motivate him. His commitment to patient care was further reinforced by his own experience as a […]