School of Medicine

Smoking is more common among kids with attention deficit-hyperactivity disorder (ADHD) than those without the disorder, but the risk for smoking rises dramatically in those with the inattentive subtype of ADHD.Advances in medical imaging techniques are among the breakthroughs being presented by Washington University researchers at the Society of Nuclear Medicine’s 50th Annual Meeting June 21-25 at the Ernest N. Morial Convention Center in New Orleans, La. More than 3,600 specialists in the field of nuclear medicine are expected to attend the meeting, which focuses on current issues in nuclear medicine, including bioethics, terrorism using radioactive materials, and controversial topics in the future of PET. WUSTL-related news from the meeting includes research on a new MicroPet technique for improved imaging of small animals and a study suggesting that FDHT-PET scanning of androgen receptors (AR) is successful in imaging patients with prostate cancer. Washington University cancer imaging specialist Barry A. Siegel will receive the Society of Nuclear Medicine’s (SNM) 2003 Georg Charles de Hevesy Nuclear Pioneer Award for his distinguished contributions to nuclear medicine.

A team of researchers from Washington University School of Medicine in St. Louis, the Mayo Clinic in Rochester, Minn., the Harvard School of Public Health and several other clinical centers around the United States has found that treating depression and social isolation in recent heart attack patients does not reduce the risk of death or second heart attack. Results from the Enhancing Recovery in Coronary Heart Disease Patients Study (ENRICHD) are published in the June 18 issue of the Journal of the American Medical Association.

Rendering of a human kidney”Most experts believe that kidney disease is caused by an immune response against the kidney,” explains principal investigator Andrey S. Shaw, M.D., professor of pathology and immunology at Washington University School of Medicine in St. Louis. “But our evidence suggests that defects that are intrinsic to the kidney also contribute to kidney failure.”

Carl M. Bender, Ph.D., and Thomas A. Woolsey, M.D., professors at Washington University in St. Louis, have been awarded fellowships from the John Simon Guggenheim Memorial Foundation. Bender and Woolsey are among 184 U.S. and Canadian Guggenheim fellows selected this year from more than 3,200 applicants for awards totaling $6,750,000. Guggenheim fellows, which include artists, scholars and scientists, are appointed on the basis of distinguished achievement in the past and exceptional promise for future accomplishment.

*Culex pipiens*, a breed of mosquito known to carry the West Nile VirusIt was a cold winter in much of the country. That’s bad news for mosquitoes, but a wet spring in much of the United States will be a benefit to the buzzing bugs. Vector control specialists have plans in place to eradicate as many mosquitoes as possible, in part to prevent another summer of the West Nile Virus. In 2002, there were more than 4,000 cases reported in the United States, and almost 300 people died. The virus also decimated bird populations. This summer Michael Diamond, M.D., Ph.D., an infectious disease specialist at Washington University School of Medicine in St. Louis, believes the situation could worsen if the virus continues to be carried by mosquitoes that bite humans more than birds. Most cases in the United States still involve livestock, and a vaccine for animals recently was approved, but no vaccine exists for humans.

Genetic factors influence nicotine withdrawal symptoms and make it difficult for some smokers to quit.Researchers at Washington University School of Medicine in St. Louis have uncovered evidence linking genetic influences to nicotine withdrawal symptoms that commonly occur when a smoker attempts to quit. Their findings also indicate that genetic factors both related and unrelated to nicotine withdrawal may affect attempts to quit smoking. The team, led by Hong Xian, Ph.D., research assistant professor of medicine at Washington University School of Medicine and researcher at the St. Louis Veterans Affairs Medical Center, found that genetic influences accounted for 54 percent of failures to quit smoking, and that about one-third of such failures could be attributed to the severity of nicotine withdrawal symptoms.

From the 2000 debate at WUSTL, then Gov. Bush answers a question while V.P. Gore looks on.Studying twins, researchers at Washington University School of Medicine in St. Louis have found a link between attention deficit-hyperactivity disorder (ADHD) and cigarette smoking. There are two major subgroups of children with ADHD. One group combines attention problems with hyperactivity and impulsivity. The other principle type of ADHD involves only attention problems. While looking for genetic factors that might be related to these two subtypes of ADHD, the research team, led by Richard D. Todd, M.D., Ph.D., the Blanche F. Ittelson Professor and director of the William Greenleaf Eliot Division of Child Psychiatry, found that children who suffer from the form of ADHD that includes only attention problems are less likely to receive treatment for the disorder and much more likely to smoke cigarettes. The researchers believe the nicotine in cigarettes may help these children improve their ability to pay attention.

Medical Science & Health Tip Sheet

Nanoparticles can be loaded with a variety of things, including imaging agents and drugs.Using nanoparticles, researchers at Washington University School of Medicine in St. Louis hope to send imaging agents and medications directly to specific cells. The research team recently received a three-year contract from the National Cancer Institute to explore nanoparticle technology for cancer detection and treatment. They also have reported success at detecting very early stages of heart disease. The researchers load specific drugs or imaging agents onto nanoparticles. Then, by injecting those packed particles into a patient, they are able to use MRI scans to locate very tiny blood vessels that tend to grow around plaques in cardiac arteries and near tumor cells at the earliest stages of cancer.

The enlarged and distended lungs of an emphysema patient before surgery.Known as lung-volume reduction surgery, the procedure improves overall health and quality of life for people with end-stage emphysema. Now lung surgeons at Washington University School of Medicine in St. Louis have found that the positive effects last for as long as five years in more than half of all patients. It is not a cure for emphysema, but studies suggest that the surgery can increase breathing capacity by more than 50 percent. The procedure was developed a decade ago at Washington University and Barnes-Jewish Hospital. In select patients with disease that is localized to certain areas of the lung, it is possible to remove the most diseased portions of lung tissue and provide more room for the lung to expand inside the chest cavity.