School of Medicine

A fluroescent-tagged antibody bearing silver and gold particles reveals I and L bradykinin receptors lit in a ghostly green glow on the surfact of cultured human cellsPreliminary research suggests it may someday be possible to diagnose and forecast risk for Alzheimer’s disease using skin cells, thanks to a small protein, or peptide, that few previously associated with the disease. Researchers at Washington University School of Medicine in St. Louis have discovered that skin cells from people with inherited forms of Alzheimer’s disease respond to the peptide by triggering Alzheimer’s-like changes, but skin cells from healthy individuals do not. They say the findings need to be explored further in cases of non-inherited Alzheimer’s disease, but the results could eventually lead to a way of determining an individual’s risk of developing Alzheimer’s before clinical symptoms arise.

Kidney recipient Barry Hammond (left) and his brother, kidney donor Brian.More than 50,000 people in the United States are waiting for kidney transplants. Most are waiting for someone who wants to be an organ donor to die, but each year only 9,000 people on the transplant waiting list get a kidney from someone who has died, while 16,500 on the list die. Transplants from living donors have the greatest chance of working for a long time and can happen quickly, often within a year. A living kidney donor may be a family member or friend between the ages of 18 and 65. They must be healthy and have a blood type that is compatible with the recipient’s blood type. But researchers at Washington University School of Medicine, have discovered something surprising. Many interested kidney donors are not taken up on their offers to donate because the recipients are afraid donors will be harmed. As a result, many potential donor kidneys go unused.

Heavy drinking is associated with a number of problems, but one surprisingly common problem involves not remembering large chunks of time. Called alcohol-induced blackouts, these memory losses were reported by more than 39 percent of women and more than 50 percent of men studied by researchers from Washington University School of Medicine in St. Louis and the Queensland Institute on Medical Research in Australia. The researchers also found that genetic factors play a big role in whether or not a person blacks out after heavy drinking. Studying more than 2,300 pairs of Australian twins, the research team was able to determine that more than 50 percent of the risk of blacking out seems to be controlled by genetic factors, and the role of genes is even greater in people who report blacking out multiple times.

James W. Ellis, the National Law Journal‘s 2002 Lawyer of the Year, will deliver the keynote address during the School of Law’s fourth annual Access to Equal Justice conference, “Mental Health and the Law,” March 19 in the Bryan Cave Moot Courtroom of Anheuser-Busch Hall.

Washington University faculty and staff make news around the world. Following is a representative sampling of media coverage from clippings and electronic sources. For the most recent clips, see the Clips Index

Washington University faculty and staff make news around the world. Following is a representative sampling of media coverage from clippings and electronic sources.

Animal studies also indicate that brief exposure to small amounts of anesthetic drugs can trigger “significant nerve cell death,” researchers report. Click here for more medical articles

Passionate, dedicated and driven only begin to describe Fiona H. Levy, M.D., associate professor of pediatrics. As the medical director of the Pediatric Intensive Care Unit (PICU) at St. Louis Children’s Hospital, Levy oversees a multidisciplinary team that cares for critically ill children and infants. “I have been given the opportunity to make a difference […]

“Cyclotron Produced Isotopes in Biology and Medicine” will continue to support research into imaging techniques and agents. Click here for more medical articles

Lenabell tells the story of a woman with sickle cell disease — including her experimental failures as well as near-miraculous successes.