School of Medicine

Photo by Bob BostonMichael R. DeBaun shares a smile with Randice Reed, who has sickle cell disease.An $18.5 million NIH grant will fund a study of blood transfusion therapy as a possible treatment for preventing silent strokes.

Image courtesy of Cindy LustigParts of the brain involved in a “resting network” show large differences between young adults, older adults, and people with Alzheimer’s disease.Researchers tracking the ebb and flow of cognitive function in the human brain have discovered surprising differences in the ability of younger and older adults to shut down a brain network normally active during periods of passive daydreaming. The differences, which are especially pronounced in people with dementia, may provide a clear and powerful new method for diagnosing individuals in the very early stages of Alzheimer’s disease.

More than $300 million will be spent to rapidly bring the new knowledge of the human genetic blueprint to the patient’s bedside.

More than $300 million will be spent to rapidly bring the new knowledge of the human genetic blueprint to the patient’s bedside. More about BioMed 21

Photo by Bob BostonJohn F. McDonnell, Larry J. Shapiro, Philip Needleman and Chancellor Mark Wrighton visit at the Nov. 17 news conference announcing BioMed 21.The three-year grant is one of five awarded by the National Human Genome Research Institute to U.S. sequencing centers.

The University is planning a Genome Sciences and Human Genetics Program, a Center for Biological Imaging and a Division of Clinical Sciences.

Deanna M. Barch, Ph.D., doesn’t want much — she just aims to discover the cause of schizophrenia and develop a way to prevent it. Barch, associate professor of psychology in Arts & Sciences and assistant professor of psychiatry in the School of Medicine, devotes much of her research to studying schizophrenia in order to better […]

Everett Mendelsohn, one of America’s foremost historians of science, will deliver the Thomas Hall Lecture titled “Dolly and the Historians: Science, Politics and Ethics of Cloning” as part of the Washington University Assembly Series at 4 p.m., Thursday, November 13. The lecture is free and open to the public and will be held in Rebstock Hall, Room 215, located just east of Mallinckrodt Center (6445 Forsyth Blvd) on the Washington University campus.

Glucocorticoid receptors on steroids.Doctors have used steroids for decades to control autoimmune and inflammatory diseases such as rheumatoid arthritis, lupus and inflammatory bowel disease, but their potentially serious side effects — including bone loss, obesity, diabetes and growth impairment — have made it difficult to keep patients on the drugs for prolonged periods of time. Endocrinologist Louis Muglia, M.D., Ph.D., associate professor of molecular biology and pharmacology and of pediatrics at Washington University School of Medicine in St. Louis, and colleagues have recently identified a key component of steroids’ effects on the immune system, a possible first step toward developing new drugs that can offer the same benefits as steroids without the many potentially serious side effects.

Courtesy photoSome blind patients, as well as some blind animals, still show pupil constriction in response to light.We use our eyes to see, but a good deal of recent research has demonstrated that the eyes are responsible for other functions, too. Russell N. Van Gelder, M.D., Ph.D., assistant professor of ophthalmology and visual sciences and of molecular biology and pharmacology at Washington University School of Medicine in St. Louis, has teamed with researchers at several other institutions to learn more about the eye’s second, non-visual system that is important to the body’s internal clock, as well as to other functions such as hormone release. Studying mice, the research team found that even in blind animals, it is important for the eye’s non-visual system to continue working. They believe damage to this system in the eye may contribute to several health problems in humans, even in people with normal vision.