School of Medicine

Human nuclear cataract (as seen through a slit lamp)Ophthalmology researchers at Washington University School of Medicine in St. Louis have identified a key risk factor for the development of cataracts. For the first time, they have demonstrated an association between loss of gel in the eye’s vitreous body — the gel that lies between the back of the lens and the retina — and the formation of nuclear cataracts, the most common type of age-related cataracts.

WUSTL professors David N. Harris and John C. Morris were among experts commenting in a recent St. Louis Post-Dispatch story on public health implications of the discovery of mad cow disease at a Washington state dairy farm. Harris, who conducts research on prion brain proteins associated with the disease, said that no one yet knows what the protein’s regular function is. Morris, a neurology specialist, said that Great Britain’s experience with the disease suggests that most people who were exposed to tainted meat did not get sick. “It’s undeniable that there is this link (with BSE), and it’s such a scary illness that it overshadows the fact that the individual risk is quite small,” Morris said.

Chest x-ray of a lung affected by pneumoniaMany medical advances involve complicated new technologies or procedures. But Linda Mundy, M.D., associate professor of medicine and an infectious diseases specialist at Washington University School of Medicine in St. Louis, recently reported good results with a new pneumonia treatment that can be summed up in a single sentence: Get patients up out of bed earlier and more often, and they check out of the hospital an average of one day sooner. Mundy says the high volume of U.S. pneumonia hospitalizations could make the new treatment a potent cost-saver, but added that a second study of the approach, known as early mobilization, is needed to confirm the beneficial effects.

Image courtesy of William C. Chapman, M.D.William Chapman monitors his surgical instrument’s position on corresponding CT scans during liver surgery.Despite being the largest vital organ in the body, the liver has very few identifiable landmarks to help guide a cancer surgeon around its surface. Two-dimensional ultrasound images currently are the standard navigational tool, making it difficult to discern depth and location in the liver during surgery to remove tumors. That’s why a research team led by William C. Chapman, M.D., professor of surgery and chief of the Abdominal Transplantation Section at Washington University School of Medicine in St. Louis plans to launch trials examining the use of three-dimensional imaging techniques to complement ultrasound during liver surgery. The research team will investigate standard three-dimensional imaging techniques like MRI, CT scanning and PET for guiding surgeons during tumor removal surgery.

The mind and the body are intimately linked, but although more and more research is demonstrating that the mind plays a role in sickness and in health, little is understood about how a person’s mental health affects physical health. A Washington University team of investigators led by Ray E. Clouse, M.D, professor of medicine and psychiatry, and Patrick J. Lustman, Ph.D., professor of psychiatry, hopes to change that by launching a new Center for Mind/Body Research that will focus specifically on ways that mental health affects heart disease, diabetes, cancer and other illnesses. New research has shown, for example, that although women are at a lower risk for heart attacks than men, the risk for women with diabetes and depression is virtually identical to what’s seen in men. The investigators believe that depression is the main cause of that increased risk, but they hope that by focusing more closely on mind/body interactions they will be able to understand more about the relationship between mental health and physical well being.

December/January Medical Science & Health Tip Sheet

Researchers found that the treatment blocked bone metastases and reduced the development of new tumors in certain organs.

Photo by Bob BostonThe Parkway Hotel has been specifically designed to serve the School of Medicine and Barnes and Children’s hospitals.The staff of the $25 million hotel “has been trained to go out of its way for our visitors,” General Manager April Risk said.

“No studies to date have looked systematically at the psychiatric effects on people who were employed in the towers,” investigator Carol S. North said.

Peanut butter could save the world. If Mark J. Manary, M.D., has his way, that ooey, gooey lunchbox staple might be some kids’ best hope for the future. Manary, associate professor of pediatrics, started a program two years ago that has saved hundreds of starving children in one of the poorest countries in southern Africa. […]