Four elected to American Academy of Arts and Sciences

Carl Frieden, Jeffrey I. Gordon, John F. McDonnell and Carl Phillips can now stand proudly beside Ben Franklin, George Washington, Albert Einstein and Winston Churchill. Those four from Washington University in St. Louis have joined those four from history as being elected into the American Academy of Arts and Sciences.

Low receptor levels and low mood

Areas of red and yellow show increased uptake of the altanserin tracer due to binding to the serotonin receptors.Most of us feel sad from time to time, even very sad, but during a bout of clinical depression, a person is unable to escape their low mood for several weeks at a time. A popular and effective treatment for depression involves a class of drugs called selective serotonin reuptake inhibitors (SSRIs). Those drugs increase serotonin levels in the brain and help relieve symptoms of depression, and most scientists believe the brain chemical serotonin plays a key role in depression. Now neuroscience researchers at Washington University School of Medicine in St. Louis have found that in people who are depressed, a key brain structure has an abnormally low number of cellular serotonin receptors.

The balancing act

There’s a telling slip of the tongue when Janet S. Rader, M.D., associate professor of obstetrics and gynecology and of genetics, lists the things she enjoys about her job. “I love taking care of patients,” Rader says, “I love doing research, I love being a mom … ” Rader pauses for a split-second to reorient […]

Early start

Neurons that have been infected with West Nile Virus.The cold winter is over, and spring rains and warmer weather mean that mosquito season is coming. Since 1999, summer mosquitoes have meant a risk for West Nile Virus. No one knows what 2004 will bring, but the season seems to have started early. The Centers for Disease Control and Prevention (CDC) already is reporting the presence of the virus in mosquitoes, birds and other animals in nine states. There even is confirmation of a human case in Ohio. Infectious diseases specialists at Washington University School of Medicine in St. Louis remind that the people at greatest risk are those 50 and older and those with weakened immune systems. Younger people also can acquire the infection, but their risk is significantly lower.
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