School of Medicine

When a major branch of the mouse immune system is disabled, a normally harmless virus can rapidly mutate into a lethal one, according to WUSM researchers. These findings may help clinicians better understand how otherwise harmless viruses can cause severe disease among patients with weakened or suppressed immune systems.

Photo courtesy of Alzheimer’s Association, St. Louis ChapterA WUSTL psychologist says there is little consensus among doctors when it comes to disclosing a dementia diagnosis to patients and their caregivers.To tell or not to tell, that is the question. Should Alzheimer’s disease patients be told of the diagnosis? If so, when, how and by whom? Brian D. Carpenter, Ph.D., an assistant professor of psychology in Arts & Sciences at Washington University in St. Louis, conducted a review of related study literature that shows there is little consensus among clinicians on the issue of disclosing a dementia diagnosis and great room for much more research. Carpenter’s review, done with research assistant Jennifer Dave, was published in the April 2004 issue of The Gerontologist. “If contemporary debate and practice are any indication, there is no consensus on these matters,” Carpenter says in the article “Disclosing a Dementia Diagnosis: A Review of Opinion and Practice, and a Proposed Research Agenda.”

That’s using your brain. For the first time in humans, a team headed by researchers at Washington University in St. Louis has placed an electronic grid atop patients’ brains to gather motor signals that enable patients to play a computer game using only the signals from their brains.

WUSTL researchers have found no convincing evidence that people can delay or hasten their own deaths through sheer will.Many of us know stories about terminally ill friends or relatives who were able to battle their illnesses in order to survive until a birthday or other important occasion. In much of medicine, it’s an accepted “truth” that people can hang on or give up and somehow influence the timing of their own deaths. But in reviewing every study on the subject of delaying death, Washington University behavioral medicine researchers have found that there’s no evidence to support the idea that terminally ill people can have an effect on when they die.

In this micrograph of a neuron, green dye highlights proteins linked to nerve cell damage and death during stroke.Brain cells in danger of exciting other nearby brain cells to death may be able to close temporarily, according to new research from Washington University School of Medicine in St. Louis. Scientists simulated stroke-like conditions in cultured rat brain cells that use glutamate, an excitatory chemical messenger linked to nerve damage and death during strokes. But when they created those conditions, the researchers found that glutamate transmission was suppressed in what may be an attempt by neurons to limit the damage caused by catastrophic events such as strokes.

GrigsbyDoctors regularly use positron emission tomography (PET) scans to diagnose cervical cancer, taking advantage of the technique’s ability to highlight metabolic differences in cancerous tissues. But PET is rarely used for follow-up assessment of cervical cancer patients after treatment. A study in the June 1 issue of Journal of Clinical Oncology shows that post-treatment PET scans could help physicians better predict which patients are largely cancer-free as a result of their treatment and which patients may soon be likely to need additional treatment.

Lung transplantation increases the survival of patients with cystic fibrosis (CF) by an average of almost four-and-a-half years, according to research led by Washington University School of Medicine in St. Louis.

The American Society for Clinical Investigation has honored Daniel Brennan, David Holtzman, Barry Sleckman and Dwight Towler.

Music, games, prizes and Ted Drewes frozen treats will be included in the event from 11 a.m.-2 p.m. at Hudlin Park.

courtesy photoOscar Segovia works with physical therapist Cassandra Pate at the Rehabilitation Institute of St. Louis.After Oscar Segovia was hit by a car while riding his motorcycle home from work, he was determined to walk again.