School of Medicine

Researchers knew that prions, the misfolded proteins that cause mad cow disease and other brain disorders, were killing off a class of important brain cells in a transgenic mouse model. But when they found a way to rescue those cells, they were astonished to discover the mice still became sick.

Rendering of the new CORTEX buildingEfforts to develop a significant biotechnology industry in St. Louis got a major boost with the groundbreaking for a new laboratory and office building that will provide space for growing companies. The new building at 4300 Forest Park Avenue in midtown St. Louis is being developed by CORTEX, the Center of Research, Technology & Entrepreneurial Exchange.

Jeffrey Petersen uses laser heat to treat varicose veins.Some 41 percent of American women may have varicose vein disease by the time they reach their 40s and 50s. Now Washington University in St. Louis dermatologic surgeons are among a growing group of physicians offering a procedure that uses heat to treat the problem.

Bobtail squidA molecule that triggers damaging changes in the lungs of children with whooping cough lets a bobtail squid living off the coast of Hawaii acquire the ability to glow, scientists have discovered.

Neuroscientists at the School of Medicine have received a five-year, $11.6 million grant to fund a Silvio O. Conte Center for the Neuroscience of Mental Disorders. Since 2001, the National Institute of Mental Health (NIMH) has funded a feasibility center at Washington University, but the new grant upgrades the center’s status, funding and number of research projects.

Daniel P. Kelly, M.D., director of the Center for Cardiovascular Research and co-director of the Cardiovascular Division at Washington University School of Medicine in St. Louis, has been named the Alumni Endowed Professor of Cardiovascular Diseases.

An improved stem cell transplant regimen that is well-tolerated and has a high success rate has been developed by researchers at the School of Medicine. The procedure holds promise for treatment of blood and bone marrow disorders, immune dysfunction and certain metabolic disorders.

Scientists who developed the new technique reported it may already have led them to a good target for vaccine development.

Photo by Robert BostonAn art show Nov. 18 at the Bernard Becker Medical Library’s King Center benefitted the Center of Creative Arts’ Urban Arts Program in St. Louis.

Salmonella entericaEvery year in developing nations, typhoid fever infects more than 16 million people and kills more than half a million. Researchers hoping to reduce this heavy toll have an important new tool: completed genomes for the two bacteria that are the leading causes of typhoid fever.