WUSM researchers aim to increase African-American blood donations

Sen. Jim Talent, Michael DeBaun and Isaac Singleton Jr. help raise awareness about sickle cell disease at a recent stamp dedication ceremony.In sickle cell disease, red blood cells change from their normal round shape to a curved, or sickle-shape. Sickle-shaped cells become stuck in blood vessels, causing damage to tissues and organs. WUSM pediatric hematologist Michael DeBaun says that ongoing blood transfusion therapy is vitally important for children with sickle cell disease, and treatment requires a sufficient supply of blood from African-American donors. “Black History Month is an ideal time to encourage African-Americans to come out and donate blood,” he says.

Bacterial target may be ideal for new drug treatments

E. Coli (yellow) attaches to a host cell using sticky fibersNew insights into the bacteria responsible for urinary tract infections appear to open up an opportunity for disabling a wide range of infectious bacteria. Researchers at the School of Medicine recently revealed how a protein known as PapD helps E. coli assemble sticky fibers called pili that allow the bacterium to latch onto and infect host cells. Scientists are using what they’ve learned to begin designing pilicides, new treatments that stop pili formation and disrupt the infection process.

Incredibly dedicated

Photo by Robert BostonRuth Guzman receives the 2004 Dean’s Distinguished Service Award — the highest honor given to a medical staff member.
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