School of Medicine

“We don’t have to start from scratch because these drugs are already approved chemotherapy agents,” says senior investigator David Gutmann.

Photo by Robert BostonJonathan D. Gitlin will serve as director of the new Division of Genetics and Genomic Medicine in the Department of Pediatrics.It incorporates a model of individualized medical care in which physicians look to a patients’ genetic makeup to determine the best treatment. More medical news

Magnified nanoparticlesSpecially designed nanoparticles can reveal tiny cancerous tumors that are invisible to ordinary means of detection, according to a study by researchers at Washington University School of Medicine in St. Louis. Researchers demonstrated that very small human melanoma tumors growing in mice — indiscernible from the surrounding tissue by direct MRI scan — could be “lit up” and easily located. Because the nanoparticles can be engineered to carry a variety of substances, they also may be able to deliver cancer-fighting drugs to malignant tumors.

Yellowing of the eye’s lens due to age-related nuclear sclerotic cataractResearchers at Washington University School of Medicine in St. Louis may be a step closer to understanding what causes cataracts, with the hope of one day being able to prevent them. In a new study published in the American Journal of Ophthalmology, the researchers report oxygen may be the culprit.

Drosophila melanoFor years, two schools of thought have dominated neurobiologists’ theories about how early nerve cells develop specialties that allow the assembly of a mature brain. One theory suggests master regulators trigger the development, while the other attributes the development to interactions between local factors. In a new study of developing fruit fly brain cells, scientists at Washington University School of Medicine and Harvard University showed that both models are valid.

The brighter signal over the transgenic heart indicates fat uptake and metabolism are greatly increased.Heart disease is the leading cause of death among the more than 13 million diabetics in the United States. Researchers at Washington University School of Medicine in St. Louis have found that in mice whose heart muscles take up high amounts of fat, the heart fills abnormally after each contraction, a condition that is consistent with the first stage of heart dysfunction in human diabetics.

Combinatorial chemistry provides researchers a vast library from which to choose.A researcher studying drug design for nerve damage therapies has gotten her answer to questions by following some old advice: she used the library. It’s not the kind of library her mother or teacher suggested, but a combinatorial chemistry library of many different protein sequences that some day might help her and her colleagues develop a successful timed drug delivery system.

A WUSTL researcher has identified a bacterium as the pathogen living on bubbles in hot water environments.A team of researchers, led by an environmental engineer at Washington University in St. Louis, has applied a molecular approach to identify the biological particles in aerosol responsible for making employees of a Colorado hospital therapeutic pool ill. They found: when the bubble bursts, the bacteria disperse, and lifeguards get pneumonia-like symptoms.

The first detailed studies of two of the largest human chromosomes have revealed enormous gene “deserts” lacking any protein-coding sequences and relics of the merger of two ape chromosomes to form a single human chromosome.

Researchers at the School of Medicine are seeking volunteers to participate in a study to determine if botulinum toxin (Botox) injections can help heal diabetic foot ulcers.