Disabling gene defuses rheumatoid arthritis in mice

Scientists studying mice have identified a gene that allows immune cells known as neutrophils to protect themselves from the inflammatory chemicals they secrete. Researchers at the School of Medicine showed that knocking the gene out in mice prevented the development of an arthritis-like disorder by making the neutrophils victims of their own damaging secretions.

A jack-of-all-trades

In its Clinical and Translational Research Program, the Siteman Cancer Center runs about 350 clinical trials simultaneously, gathering health information from hundreds of patients. To set up each study and analyze the resulting data requires expertise in biostatistics. This keeps J. Philip Miller, the biostatistics core director at Siteman, very busy. He and his staff […]
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