School of Medicine

Children between the ages of 6 and 17 years old with moderate-to-severe asthma may be eligible for a study at the School of Medicine to evaluate whether two medications can reduce the amount of inhaled steroids needed to control asthma.

The high-fat “diet” that diabetic heart muscle consumes helps make cardiovascular disease the most common killer of diabetic patients, according to a study done at the School of Medicine. The study will appear in the February 7 issue of the Journal of the American College of Cardiology and is now available online.

Photo by Robert BostonHelping kick off St. Louis Children’s Hospital’s “Building for Care, Searching for Cures” campaign were Joe Buck, Jonathan D. Gitlin, Lee Fetter and Larry Shapiro.The collaboration will focus on accelerating cures in four areas: congenital heart disease, cancer, lung and respiratory disorders and musculoskeletal diseases. More medical news

Warfarin, also known by the brand name Coumadin, is often given to patients with atrial fibrillation, irregular contractions of the upper chambers of the heart.

Surgeons once treated blockages with a carotid bypass, which reroutes a scalp artery to restore normal brain blood flow and pressure.

“We’re analyzing the genes active in breast tumors to characterize the biological behaviors of each breast-cancer subtype,” says lead investigator Matthew Ellis.

Photo by Tim ParkerMedical students in the Ballroom Dance Club learn dances for the School of Medicine’s 10th annual Faculty/Student Med Ball, to be held March 11.

Listed below are this month’s featured news stories. • Warfarin increases risk of fractures (week of Feb. 1) • Older adults can control health (week of Feb. 8) • New cancer strategy (week of Feb. 15) • Enzyme affects aging process (week of Feb. 22)

Bright areas in this image highlight the junctions between heart muscle cells.Failing hearts develop interference in their communication channels, according to research conducted at Washington University School of Medicine in St. Louis. The problem involves a subtle change in the pores that connect heart muscle cells. When the scientists duplicated this change in mice, the mice became susceptible to ventricular tachycardia, a dangerous heart rhythm disorder that can lead to sudden cardiac death.

Mice with Tax-induced leukemia/lymphoma develop large tumors and many areas of bone destruction, as shown in this X-ray.Defeating cancerous tumors by attacking healthy cells seems like an unusual strategy, but researchers at Washington University School of Medicine in St. Louis have shown the strategy to be effective against leukemia/lymphoma in mice. The research group found that inhibiting normal bone-maintenance cells called osteoclasts not only prevented the mice’s cancer from spreading to their bones, it also slowed the growth of tumors in the body’s soft tissues.