School of Medicine

So you think you know what your parents want? A psychologist at Washington University in St. Louis is conducting research that shows two adult siblings may have radically different views on what their parents would want. In fact, he says that a random stranger might have the same chance at guessing parental wishes as some children would.

Mechanical engineers at Washington University in St. Louis and their collaborators have devised a technique on humans that for the first time shows just what the brain does when the skull accelerates. What they’ve done is use a technique originally developed to measure cardiac deformation to image deformation in human subjects during repeated mild head decelerations.

The eyes have it — a design to manage aspects of movement.The design of the eye and the muscles and bone that surround it help the brain manage certain complex aspects of eye movement, according to researchers at Washington University School of Medicine in St. Louis. The finding, published in Neuron, may help push an old debate about how eye movement is controlled toward resolution and help eye surgeons better diagnose and treat disorders such as strabismus (crossed eyes) that lead to misalignment of the eyes.

Repair proteins (bright green areas) are inhibited from gathering at sites of DNA damage.To remain healthy, all cells must quickly mend any breaks that arise in their DNA strands. But cancer cells are particularly dependent on a process called homologous recombination to repair DNA and stay alive. Now researchers at Washington University School of Medicine in St. Louis have identified a protein with a role in homologous recombination, and the discovery could be exploited as part of a two-pronged treatment strategy to kill cancer cells by eliminating their ability to repair DNA.

WUSM researchers have developed a diagnostic tool for identifying pathological gambling disorder.More than 80 percent of the U.S. population gambles at some time in their lives. It might be the lottery, bingo or poker. Most never need treatment for problem gambling, but others lose control and lose their houses or cars and damage family relationships as a result of compulsive gambling. Little is known about why people gamble and how to predict who is likely to become a pathological gambler, but Washington University researchers have developed a diagnostic tool for identifying pathological gambling disorder, and they’re beginning to learn who is at risk.

Structure of the fatty acid receptor CD36As you stand at buffet tables during holiday parties this year, it might cheer you up to know most people don’t gain as much weight over the holidays as once was thought. Instead of five or 10 pounds, most of us actually gain only a pound or two. But it might depress you to know that weight gain happens one pound at a time, and in the long run, it may be hard to avoid — especially for some of us, because some of the taste buds in our tongues are programmed to make us crave fatty food — and fat is everywhere in our diets. French researchers recently reported that mice have a receptor in their tongues that can sense fat, and the presence of that receptor seems to drive the mice to crave fat in their diets. The research was based on work from scientists at Washington University School of Medicine in St. Louis, where investigators previously had identified a protein receptor for fat and documented its function in recognizing and using fatty food.

Mania can be confused with ADHD.Child psychiatry researchers at Washington University School of Medicine in St. Louis have identified a small group of preschoolers who appear to suffer from bipolar disorder, also known as manic-depressive illness. In findings presented this fall to the American Academy of Child and Adolescent Psychiatry, the researchers reported they had identified key symptoms that distinguish bipolar disorder from other problems in very young children. Diagnosing bipolar disorder in childhood can be difficult because the manic phase of the illness can be confused with the more common attention deficit hyperactivity disorder (ADHD). The confusion arises because mania and ADHD both involve hyperactivity, irritability and distractibility.

The Department of Psychiatry at the School of Medicine is hosting a program on strategies to help patients with treatment resistant depression.

The Story Link program lets prisoners talk to their children via cassette tapes.Thousands of Missouri inmates have been given a chance to reconnect with their children thanks to a volunteer program led by WUSM’s Dana and Jane Abendschein. The Story Link program allows inmates to record messages and children’s stories onto a cassette, which is then mailed to their families. For many inmates, it’s the only form of communication they have with their children.

By peering into the minds of volunteers preparing to play a brief visual game, neuroscientists at the School of Medicine have found they can predict whether the volunteers will succeed or fail at the game.