School of Medicine

Perlmutter (left) checks the lighting at a work area of client Gay Hirsch, who has low vision.Monica Perlmutter is taking her “show on the road” to help older adults with low vision live independently in their homes. Nearly 4 million adults age 65 and older have visual impairment severe enough to interfere with daily activities. Macular degeneration, diabetic retinopathy, inoperable cataracts and glaucoma are leading causes of low vision.

Children treated for sickle cell disease have worse symptoms if they are also asthma sufferers, physicians at the School of Medicine noted. Further, children with asthma often also have breathing disturbances during sleep.

Pitchers often lose range of motion in their pitching elbows.Now that the Chicago White Sox have swept the Houston Astros in the World Series, most baseball players are taking some time to rest. Time off is especially important for pitchers because throwing a baseball overhand is both an unnatural motion and a burden on the shoulder and elbow. Now a research team led by Washington University sports medicine specialists has found that professional pitchers have significantly decreased range of motion in their throwing elbows. But that limited range of motion doesn’t seem to be influenced by the age of the pitcher, how many innings he has pitched or whether he has a history of injuries.

A dotted line indicates the former position of the thyroid in this child.When a child inherits an abnormal gene that leads to thyroid cancer, surgical removal of the thyroid gland before the cancer spreads is the only sure cure. Now a new study shows it is best to take out the thyroid before a child turns eight to guarantee a life free of thyroid cancer. The researchers tracked the effectiveness of preemptive thyroid removal in 50 at-risk children ranging in age from three to 19 years. All patients were followed for at least five years at Washington University School of Medicine and at Duke University School of. The surgeons found that none of the 22 children who were under eight at the time of surgery showed signs of thyroid cancer five or more years later. However, they did find indications of thyroid cancer in six of the 28 children who were older than eight when they had surgery to remove the thyroid gland.

Tasks requiring shifting of attention, like driving a car while conversing with a passenger, may be challenging for people in very early stages of Alzheimer’s disease.People in early stages of Alzheimer’s disease have greater difficulty shifting attention back and forth between competing sources of information, a finding that offers new support for theories that contend breakdowns in attention play an important role in onset of the disease. Published in a recent issue of the journal Neuropsychology, the study suggests that subtle breakdowns in attention may offer one of the earliest reliable clues that a patient is grappling with early symptoms of Alzheimer’s-related dementia.

Detecting breast cancer recurrence with a simple blood test.Physicians treating women with breast cancer recognize the need for a specific and sensitive method to monitor disease recurrence, so they should be encouraged by a new study that describes a biomarker that seems to fill those criteria. Researchers at Washington University School of Medicine in St. Louis have shown that mammaglobin, a protein secreted by breast tumor cells, can readily be detected in the blood serum of patients with metastatic breast cancer using an inexpensive, reliable clinical test.

Allison Miller discusses jocotes with a man in southern Honduras.Researchers at Washington University in St. Louis report that farmers and families in Central America have saved genetic variation in the jocote (ho-CO-tay), (Spondias purpurea), a small tree that bears fruit similar to a tiny mango. And they’ve done this by taking the plants out of the forest, their wild habitat, and growing them close to home for family and local consumption Allison Miller, Ph.D., a post-doctoral researcher at the University of Colorado, and former graduate student in Arts & Sciences at Washington University, and Spencer T. Olin Professor of Biology Barbara Schaal, Ph.D., from Washington University, in conjunction with Peter Raven, Ph.D. Engelmann Professor of Botany at Washington University and Director of the Missouri Botanical Garden, have shown multiple domestications of the jocote in Central America in the midst of large-scale deforestation, a practice that endangers genetic diversity .

Sonograms show mouse tune.Research by Timothy Holy showing that mice sing in the presence of mates was picked up by news organizations around the globe. Click here to see a sampling of the media coverage.

Researchers studying a mouse model of neurofibromatosis 1 (NF1), a genetic condition that causes childhood brain tumors, have found their second new drug target in a year, a protein called methionine aminopeptidase-2 (MetAP2).

Scientists have known for decades that female lab mice or their pheromones cause male lab mice to make ultrasonic vocalizations. But a new paper from researchers at the School of Medicine establishes for the first time that the utterances of the male mice are songs.