School of Medicine

ZebrafishTo learn more about how glucose affects human development, Washington University researchers have developed the first vertebrate model of the role of glucose in embryonic brain development. The model is made up of zebrafish. Their transparent embryos develop similarly to humans, except that they grow outside of the mother’s body, where development can be more easily observed. The model provides the foundation for and insight into the roles of nutrition and genetics in human birth defects. The research also may have implications for patients with neurodegenerative diseases such as Parkinson’s. More…

Bob Boston/WUSTL PhotoTwo surgeons at the same hospital perform the same operations on patients with similar medical histories. Their costs to the hospital are similar, right? Not necessarily. There could be a difference as high as 45 percent. New research from Washington University in St. Louis finds that even when controlling for complexity of the operation and patient risk, surgeons incurred a wide range of hospital costs. More…

David Kilper/WUSTL PhotoMemory Elvin-Lewis in the Goldfarb Greenhouse inspects a kava plant. Elvin-Lewis has written a chapter in a new book that is critical of the unregulated U.S. herbal trade.Ginsengs, echinaceas, and ephedras, oh my! These herbs sound innocuous enough, however, according to Memory Elvin-Lewis, Ph.D., professor of microbiology and ethnobotany in biomedicine in Arts & Sciences at Washington University in St. Louis, Americans are unaware of the dangers inherent in these herbal supplements. More…

Courtesy image/WUSTL PhotoFor some deaf children, a plastic slide is a more formidable foe than the school wedgie-giver. Static electricity buildup from sliding down a plastic slide — instant summertime fun for those with normal hearing — can temporarily silence the world to cochlear implantees. Two electrical engineers at Washington University in St. Louis tested static electricity buildup — which can zap a cochlear implant — on sliding children to quantify the sparks. Thanks to some publicity and increased awareness, their research has inspired the St. Louis County Parks and Recreation Department to consider the problem, and an anti-static coating company to try to solve it. More…

Olga Pontes & Craig PikaardThe protein HDA6 shows up as a red stain in this Arabidopsis leaf cell nucleus.A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off — in this case, the turning off of thousands of nearly identical genes in a hybrid plant. Studying the phenomenon of nucleolar dominance, in which one parental set of ribosomal genes in a hybrid is silenced, Craig Pikaard, Ph.D., Washington University professor of biology in Arts & Sciences and colleagues have identified the protein HDA6 as an important player in the silencing. More…

Researchers at the School of Medicine have found that obese elderly people can improve their physical function and lessen frailty by losing weight and exercising.

Researchers seeking insights into kidney failure in human infants have located the source of a 30-year-old mystery mutation that causes similar problems in a mouse line.

“When colleagues have professed great satisfaction about being a part of this community, it validates what we are doing,” Chancellor Wrighton said.

Some lung cancer patients — those with conditions that raise the potential for surgical complications — can be at a high risk from a lobectomy. More medical news

Siteman’s acceptance into The National Comprehensive Cancer Network will allow the center the ability to further improve cancer care guidelines.