School of Medicine

New research may finally settle a decades-old debate about how the kidney keeps valuable blood proteins from harmfully slipping into the urine, a serious health symptom that often precedes kidney failure. WUSM scientists discovered that a structure, known as the glomerular basement membrane, plays a key role in the process.

A woman trying to conceive a child may receive as many as 1,000 fertility-enhancing injections per year, but a recent discovery at the School of Medicine may help reduce the required number of fertility shots to about one per week.

These before (left) and after images show the effects of fumagillin-laden nanoparticles in a rabbit aorta.In laboratory tests, one very low dose of a drug was enough to show an effect on notoriously tenacious artery-clogging plaques. But it wasn’t so much the drug itself as how it was delivered. Fumagillin — a drug that can inhibit the growth of new blood vessels that feed atherosclerotic plaques — was sent directly to the base of plaques by microscopically small spheres called nanoparticles.

Dark areas (marked with arrows) in the first image show a process of bone renewal and strengthening. The second image shows a reduction in this process after a cortisone injection.Scientists are closing in on the solution to a persistent medical puzzle: why do high doses of cortisone, widely prescribed for asthma, rheumatoid arthritis and other inflammatory and autoimmune conditions, weaken bones? Researchers at the School of Medicine have identified osteoclasts, cells that dismantle old bone, as the essential link between osteoporosis and cortisone.

VirginHerbert W. “Skip” Virgin has been named head of the Department of Pathology and Immunology at the School of Medicine. Virgin came to the department in 1990 as an instructor and became a professor in 2002. As the new department head, he becomes Edward Mallinckrodt Professor of Pathology and Immunology.

Computer screens are replacing X-rays and paper files.Surgeons and staff no longer wonder where’s the chart in the Division of Cardiothoracic Surgery at Washington University School of Medicine. That’s because the division switched from using paper files to a fully electronic medical record system. Electronic records are thought to improve the quality of care, reduce errors and improve efficiency. The federal government has set a goal for widespread adoption of e-records in medical practices within the next 10 years.

A School of Medicine study showed that germ-free mice that received two prominent human gut microbes got fatter.

J. William Harbour, M.D., a specialist in diagnosing and treating eye tumors, was named the Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences.

School of Medicine researchers will study whether putting a normal-weight person on calorie restriction will change markers of aging,

The new Diabetes Center at the Center for Advanced Medicine will provide a new group-care and patient-education approach.