Belly fat may drive inflammatory processes associated with disease

An abdominal MRI scan showing the locations of subcutaneous and visceral fatAs scientists learn more about the key role of inflammation in diabetes, heart disease and other disorders, new research from Washington University School of Medicine in St. Louis suggests that fat in the belly may be an important promoter of that inflammation. It’s well known that excess fat is associated with disease, but the researchers have confirmed that fat cells inside the abdomen are secreting molecules that increase inflammation. It’s the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. More…

Measuring lung motion leads to better radiation treatment for lung cancer

Parag Parikh and Kristen Lechleiter set up the 4D Phantom to simulate the motion of tumors in the lung.Tumors that move, such as those in the lung — which can change position during each breath — are a special problem for radiation oncologists. A group at Washington University School of Medicine in St. Louis has studied the way lung tissues move during breathing in hopes of improving radiation as a treatment for lung cancer. More…

Light-activated compound silences nerves, may one day help epileptics

A compound that halts nerve cell activity when exposed to light glows in this image of two nerve cells.Brain activity has been compared to a light bulb turning on in the head. Scientists at the School of Medicine have reversed this notion, creating a drug that stops brain activity when a light shines on it. The new compound activates the same receptor used by many anesthetics and tranquilizers, making it harder for a brain cell to respond to stimulation. The drug may some day be used to treat epilepsy.
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