New clues for treatment of disease that causes accelerated aging

There is renewed hope for treatment of a rare genetic condition that causes rapidly accelerated aging and leads to an average life expectancy of 13 years. Scientists studying the genes of two infants who died of mysterious illnesses found the infants had mutations in LMNA, the same gene altered in patients with the premature aging condition progeria. But the infants’ unusual mutations caused them to make many more bad copies of the gene’s primary protein, lamin A, than progeria patients.

Pattycake, Pattycake

Photo by Robert BostonThree-year-old Reuven Kirshner plays pattycake with his nurse, Sarah Parks, after he had a bone from his shin transplanted into his arm, which was affected by a rare bone cancer.

Technique monitors thousands of molecules simultaneously

David Kilper/WUSTL PhotoKevin Moeller’s group is pioneering new methods for building libraries of small molecules on addressable electrode arrays.A chemist at Washington University in St. Louis is making molecules the new-fashioned way — selectively harnessing thousands of minuscule electrodes on a tiny computer chip that do chemical reactions and yield molecules that bind to receptor sites. Kevin Moeller, Ph.D., Washington University professor of chemistry in Arts & Sciences, is doing this so that the electrodes on the chip can be used to monitor the biological behavior of up to 12,000 molecules at the same time.
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