School of Medicine

Scientists have linked a protein to the body’s use of glucose and shown its potential as a target for new drugs to treat diabetes and obesity.

When repairing severed or damaged motor nerves with a donor nerve graft, surgeons have traditionally used a sensory nerve from another area of the patient’s body. However, these patients often do not fully regain function in the injured area. But now a team of surgeons at the School of Medicine and Barnes-Jewish Hospital has found that repairing a motor nerve in rats with an intact motor nerve yields better results than using a sensory nerve. The research appeared in the March issue of the journal Microsurgery.

Scientists at the Genome Sequencing Center were among those to decode the rhesus macaque monkey genome, which shares about 93 percent of DNA with humans.

Courtesy PhotoFirst-year medical students spent a week at a Navajo Reservation in Arizona talking with middle- and high-school students about diabetes, obesity and substance abuse.

The School of Medicine has launched a wide-reaching initiative to encourage departments to hire and retain faculty from diverse backgrounds. In keeping with that initiative, the medical school will hold a symposium May 16 focusing on that mission.

DXA scans of a male patient with osteoporosisAlthough women are four times more likely than men to develop osteoporosis, or porous bone, one in 12 men also suffer from the disease, which can lead to debilitating – or even life-threatening – fractures. In women, low estrogen levels after menopause have been considered an important risk factor for this disorder. Now research at Washington University School of Medicine in St. Louis has shown that low amounts of active estrogen metabolites also can increase the the risk of osteoporosis in men.

Using an innovative statistical approach, a research team from Washington University School of Medicine in St. Louis and the University of California, Los Angeles, has identified two regions of DNA linked to autism. They found the suspicious DNA with a much smaller sample of people than has been used traditionally in searches for autism genes.

Researchers at Washington University School of Medicine in St. Louis report they have developed an agent that protects cells from the lethal effects of radiation, regardless of whether it is given before or after exposure. Using this agent in mice, the investigators found that the treatment helped shield rapidly dividing cells that are most vulnerable to radiation-induced death, providing proof in principle that it is possible to fend off radiation damage.

Women with estrogen-responsive breast cancer are often prescribed a drug that reduces their estrogen levels. But because estrogen is important to bone health, there is widespread concern about how the estrogen-reducing drugs – called aromatase inhibitors – affect bones. A study at the School of Medicine will investigate bone loss in women taking aromatase inhibitors, and researchers are calling for interested women to volunteer.

The School of Medicine is seeking online faculty input on the strategic plan being developed as part of the University-wide “Planning for Excellence” initiative.