WUSTL engineers find common ground in brain folding, heart development

Photo by David KilperLarry A.Taber, Ph.D., (left) the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, employ a microindentation device to measure the mechanical properties of embryonic hearts and brains. The researchers are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and more intellectual capacity) than a brain of comparable volume with a smooth surface.

Landmark national research initiative to examine development of St. Louis kids

The School of Medicine is participating in the largest study of child and human health ever conducted in the United States. The National Institutes of Health has selected the city of St. Louis and Macoupin County, Ill., as sites for the National Children’s Study, an extensive population-based study looking at the health and development of children by following them from before birth to adulthood.

Cholesterol metabolism links early- and late-onset Alzheimer’s disease

Although the causes of Alzheimer’s disease are not completely understood, amyloid-beta (A-beta) is widely considered a likely culprit — the “sticky” protein clumps into plaques thought to harm brain cells. But now researchers at the School of Medicine have uncovered evidence strengthening the case for another potential cause of Alzheimer’s. The finding also represents the first time scientists have found a connection between early- and late-onset Alzheimer’s.

WUSTL engineers find common ground in brain folding, heart development

Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.
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