School of Medicine

Listed below are this month’s featured news stories. • Stress and Alzheimer’s (week of June 6) • Dietary calcium is better (week of June 13) • Treating prostate problems (week of June 20) • Fireworks safety (week of June 27)

An X-ray of a case of scoliosis.Physicians have recognized scoliosis, the abnormal curvature of the spine, since the time of Hippocrates, but its causes have remained a mystery — until now. Researchers at Washington University School of Medicine in St. Louis and collaborating institutions have discovered a gene that underlies the condition, which affects about three percent of all children. The finding lays the groundwork for determining how the genetic defect leads to the C- and S-shaped curves that characterize scoliosis.

The list of reasons you shouldn’t smoke has gotten longer. Researchers at Washington University School of Medicine in St. Louis are reporting that smoking interferes with ligament healing. Each year in the United States there are more than 20 million reported ligament injuries, and MCL injuries—which affect a ligament supporting the knee joint—are the most common. Studying mice with MCL injuries, the team discovered cigarette smoking impairs the recruitment of cells to the injury site and delays healing following ligament repair surgery.

HamvasAaron Hamvas, M.D., a renowned pediatrician in newborn medicine and a leading authority on a lethal infant lung disease, has been appointed the first James P. Keating, M.D., Professor of Pediatrics at the School of Medicine. Hamvas is medical director of the Neonatal Intensive Care Unit at St. Louis Children’s Hospital and of Nursery Services at Barnes-Jewish Hospital.

Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer’s disease. Now the same group has shown that blocking a different brain peptide slows the stress-induced increase, opening a new door to treatment. Researchers from the School of Medicine report the results online this week in the Proceedings of the National Academy of Sciences.

Washington University in St. Louis is creating a new International Center for Advanced Renewable Energy and Sustainability (I-CARES) to encourage and coordinate university-wide and external collaborative research in the areas of renewable energy and sustainability — including biofuels, CO2 mitigation and coal-related issues. The university will invest more than $55 million in the initiative, according to Chancellor Mark S. Wrighton.

The newly established International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis will encourage international collaborative research on energy and environmental issues by working closely with a global partnership of leading universities forged recently by the University’s McDonnell International Scholars Academy.

The International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University in St. Louis will be shaped and supported by advisory and steering committees comprised of both internal and external leaders, Chancellor Mark S. Wrighton announced.

PakrasiThe International Center for Advanced Renewable Energy and Sustainability (I-CARES) at Washington University will operate under the direction of Himadri B. Pakrasi, Ph.D., the George William and Irene Koechig Freiberg professor of biology in Arts & Sciences, and professor of energy in the School of Engineering.

W. Donald Gay, D.D.S., has been named the Christy J. and Richard S. Hawes III Professor at the School of Medicine. Chancellor Mark S. Wrighton and Larry J. Shapiro, M.D., executive vice chancellor for medical affairs and dean of the School of Medicine, made the announcement. Before their deaths, Mr. and Mrs. Hawes established the professorship in honor of and in gratitude to Gay, who directs the Division of Maxillofacial Prosthetics in the Department of Otolaryngology. Mrs. Hawes was one of Gay’s patients.