Researchers separate analgesic effects from addictive aspects of pain-killing drugs

Mice developed in the laboratory of Zhou-Feng Chen don’t experience relief from pain when given opiate drugs such as morphine.For the first time, pain researchers at the School of Medicine have shown that it’s possible to separate the good effects of opiate drugs such as morphine (pain relief) from the unwanted side effects of those drugs (tolerance, abuse and addiction). The investigators, led by Zhou-Feng Chen, Ph.D., associate professor of anesthesiology, psychiatry and molecular biology and pharmacology, report their results online in the Proceedings of the National Academy of Sciences. They found that opiates like morphine don’t relieve pain as well in mice genetically engineered to lack neurons that produce a neurotransmitter called serotonin in the central nervous system.

Babies’ brains to be monitored using light scans

Researchers hoping to better understand the development of the infant brain have long been stymied by a formidable obstacle: babies just don’t want to sit still for brain scans. “There have been some studies that obtained brain scans of infants while they were napping or sedated, but what we’d really like to do is to scan their brains when they’re sitting on a parent’s lap, seeing new things, hearing new words and interacting with the environment,” says Joseph Culver, Ph.D., assistant professor of radiology at the School of Medicine.
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