School of Medicine

Robert BostonAveri Leahy, a junior in the Pediatric Emergency Medicine Research Associates’ Program (PEMRAP), talks with Jan D. Luhmann, M.D., assistant professor of pediatrics and a PEMRAP co-director, in the St. Louis Children’s Hospital Emergency Department. Students in the PEMRAP program check the admissions computer for patients who may qualify for clinical studies.

Scanning electron microscopy image of a filamentous bacterium from a patient with a UTIScientists at the School of Medicine have found definitive proof that some of the bacteria that plague women with urinary tract infections (UTIs) are entrenched inside human bladder cells. The finding confirms a controversial revision of scientists’ model of how bacteria cause UTIs. Previously, most researchers assumed that the bacteria responsible for infections get into the bladder but do not invade the individual cells that line the interior of the bladder.

It’s possible to keep your diet intact during the holidays.The holiday season, with all its sweet temptations, is in full swing. However, all those holiday parties and office gatherings laden with scrumptious food and drink don’t have to mean the end of your weight loss plan. It’s still possible to enjoy the bounty and not feel deprived of your favorite holiday dishes, says Connie Diekman, director of University Nutrition at Washington University in St. Louis. Video available.

WolffSt. Louis businesswoman and philanthropist Edith L. Wolff has made a commitment of $20 million to support biomedical research at the School of Medicine. The funds will establish the Alan A. and Edith L. Wolff Institute, which will support biomedical research projects that lead to the prevention, treatment and cure of disease.

Certain types of tantrums in preschoolers may be a sign of serious emotional or behavioral problems, according to researchers at the School of Medicine. Although temper tantrums are common and normal in young children, the researchers found that long, frequent, violent and/or self-destructive tantrums may indicate the presence of psychiatric illness.

Researchers at the School of Medicine have shown that a controversial phenomenon known as antibody-dependent enhancement (ADE) of infection is suppressed by C1q, a blood-borne, immune system compound. Better understanding of ADE should help public health experts and clinicians working to control some viral disease outbreaks and aid efforts to design safe and effective vaccines.

When the alert goes out that a virus has invaded the body, cells that have yet to be attacked prepare by “armoring” themselves for combat, attaching specific antiviral molecules to many of their own proteins to help resist the invader. Scientists believe adding these molecules to cellular proteins, like putting on armor, changes the proteins in ways that make the cells resistant to the coming viral attack.

James Kemp will co-lead a campaign to prevent infant death due to unsafe sleep practices with funding from an $11 million grant from the Bill & Melinda Gates Foundation. Kemp is a professor of pediatrics at the School of Medicine and a pediatrician at St. Louis Children’s Hospital. The grant, awarded to Baltimore-based First Candle, a nonprofit organization promoting infant health, will support a national campaign called “Bedtime Basics for Babies.”

A group of children who have sickle cell disease and who experience silent strokes showed some relief from the silent strokes with blood transfusion therapy, researchers at the School of Medicine have found. The study’s results will appear in a future issue of Pediatric Blood and Cancer but are available for review in its advance online publication.

Robert BostonThirty-seven second-, third- and fourth-year medical students were recognized with awards at the Student Awards luncheon Nov. 28.