Researchers hone technique to KO pediatric brain tumors

WooleyAn interdisciplinary team of researchers at Washington University in St. Louis, led by Karen L. Wooley, Ph.D., James S. McDonnell Distinguished University Professor in Arts & Sciences, is a step closer to delivering cancer-killing drugs to pediatric brain tumors, similar to the tumor that Senator Ted Kennedy is suffering from. Such tumors are often difficult to completely remove surgically; frequently, cancerous cells remain following surgery and the tumor returns. Chemotherapy, while effective at treating tumors, often harms healthy cells as well, leading to severe side effects especially in young children that are still developing their brain functions. In an effort to solve this problem, the Wooley lab has developed polymeric nanoparticles that can entrap doxorubicin, a drug commonly used in chemotherapy, and slowly release the drug over an extended time period.

Stem cell transplant for sickle cell disease subject of clinical trial

Children with sickle cell disease often face severe pain, organ damage, recurrent strokes and repeated, prolonged hospital stays. Although there are medical interventions that can lessen the symptoms, there is no cure. Researchers at the School of Medicine are leading a nationwide, multicenter clinical trial to determine the effectiveness of transplanting blood stem cells from unrelated donors into children with severe sickle cell disease.

New hearing aid technology passes the restaurant noise test

The sound of a noisy Chicago restaurant during the breakfast rush — the clang of plates and silverware and the clamor of many voices — was the crucial test of new hearing aid technology in a study conducted by researchers at the School of Medicine. The study showed that the hearing aids worked well in a noisy environment — the most challenging test for a hearing aid.
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