Form of Crohn’s disease traced to disabled gut cells

Scientists report in this week’s Nature that they have linked the health of specialized gut immune cells to a gene associated with Crohn’s disease, an often debilitating and increasingly prevalent inflammatory bowel disorder. The link to immune cells intrigued researchers at the School of Medicine because they and others believe Crohn’s disease is caused by misdirected immune responses in the intestine that damage gut tissue.

Direct recording shows brain signal persists even in dreamless sleep

Scientists used a direct monitoring grid of electrodes (left) and functional magnetic resonance imaging (right) to detect a low-frequency brain signal that doesn’t stop, even in sleep.Neuroscientists at the School of Medicine have taken one of the first direct looks at one of the human brain’s most fundamental “foundations”: a brain signal that never switches off and may support many cognitive functions. Their results are an important step forward for efforts to outline what neuroscientists call the functional architecture of the brain. Better understanding of this architecture will aid efforts to treat brain injury and mental disorders.

Researchers note differences between people and animals on calorie restriction

Calorie restriction, a diet that is low in calories and high in nutrition, may not be as effective at extending life in people as it is in rodents, according to scientists at the School of Medicine. Previous research had shown that laboratory animals given 30 percent to 50 percent less food can live up to 50 percent longer, but new research suggests the diet may not have the desired effect unless people on calorie restriction also pay attention to their protein intake.
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