Manary named Helene B. Roberson Professor of Pediatrics

ManaryMark Manary has been named the Helene B. Roberson Professor of Pediatrics at the School of Medicine. “Mark Manary is an outstanding choice for the Helene B. Roberson Professor of Pediatrics,” said Chancellor Mark S. Wrighton. “Dr. Manary has developed innovative approaches to improving the lives of children in Africa. He is a credit to his field and most deserving of this generous honor supported by an endowment gift from Helene B. Roberson.”

Lung cancer vaccine to be evaluated at Siteman Cancer Center

A vaccine designed to prevent the recurrence of lung cancer is now being tested in centers around the world including the Siteman Cancer Center at the School of Medicine and Barnes-Jewish Hospital. The vaccine stimulates the immune system to destroy cells that carry a tumor-specific antigen called MAGE-A3. This antigen is not present in normal tissue but is found in several cancer types, including 35 percent to 50 percent of cases of the most common type of lung cancer, non-small cell lung cancer.

Model unravels rules that govern how genes are switched on and off

Illustration by Michaela HuntFor years, scientists have struggled to decipher the genetic instruction book that details where and when the 20,000 genes in a human cell will be turned on or off. Different genes operate in each cell type at different times, and this careful orchestration is what ultimately distinguishes a brain cell from a liver or skin cell. Now, scientists at the School of Medicine report they have developed a model of gene expression in yeast that predicts with a high degree of accuracy whether a gene will be switched on or off.
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