School of Medicine

Neurobiologists at the School of Medicine have identified pathways that allow microscopic worms to survive in a low-oxygen, or hypoxic, environment. They believe the finding could have implications for conditions such as stroke, heart attack and cancer. Sensitivity to low oxygen helps determine how damaging those medical conditions can be.

Researchers seeking ways to defeat malaria have found a way to get help from the parasite that causes the disease. Scientists at the School of Medicine stepped aside and let Plasmodium falciparum, one of the deadliest strains of malaria, do a significant portion of the genetic engineering work in their new study.

Half of the immune system has a hidden talent, researchers at the School of Medicine have discovered. They found the innate immune system, long recognized as a specialist in rapidly and aggressively combating invaders, has cells that can learn from experience and fight better when called into battle a second time. Scientists previously thought any such ability was limited to the immune system’s other major branch, the adaptive immune system.

Two international teams of researchers have made significant gains in understanding the genetic basis of psoriasis, a chronic skin condition that can be debilitating in some patients. Their research, involving thousands of patients, is reported in two studies published this week in the advance online Nature Genetics.

Washington University graduate student Kim Lorenz collects yeast samples from Pennsylvania oak trees as part of a project to analyze how genes interact to produce complex traits.In recent years, genetic studies have uncovered hundreds of DNA variations linked to common diseases, such as cancer or diabetes, raising the prospect that scientists can gauge disease risk based on information in an individual’s genome. But the variations identified to date only account for a small percentage – typically one to three percent – of the overall genetic risk of any common disease.

Lodge Jennifer Lodge has been named associate dean for research at the School of Medicine. The appointment is effective Feb. 1, 2009. In the newly created position, Lodge will coordinate efforts to advance research at the school, focusing particularly on projects that involve multiple departments, multiple disciplines and core facilities that can serve a wide variety of researchers.

Gross (left) and Xianlin Han analyze samplesResearchers at the School of Medicine, led by heart specialist Richard Gross, are studying how altered fat metabolism causes heart failure in diabetic patients. They have received a five-year, $11 million grant from the National Institutes of Health to continue their investigations.

Many older adults worry — a lot. Almost one in 10 Americans over age 60 suffer from an anxiety disorder that causes them to worry excessively about normal things — like health, finances, disability and family. Although antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs) can improve anxiety symptoms in younger adults, little has been known about their effects in older people. In the largest study of SSRIs in older people with anxiety disorders, a team of psychiatric researchers found the drug escitalopram (Lexapro®) improved anxiety symptoms and quality of life.

WilsonWilliam Julius Wilson, one of the nation’s leading scholars on race and urban poverty, will deliver this year’s Martin Luther King Jr. celebration lecture at 4 p.m. Jan. 19 in the Eric P. Newman Education Center, 320 S. Euclid, on the School of Medicine campus.

Marcia Munk, Universidade Federal de São PauloWhat if free exercise classes were offered in public spaces such as parks, beaches and recreation centers? When a city government in Brazil tried such a program, it greatly increased physical activity among community members. A group of health researchers who studied the program believes it could also work in U.S. cities with warm climates.