School of Medicine

New research shows that in Missouri the disparity in cancer incidence and death between African-Americans and whites is declining.

Scientists used a direct monitoring grid of electrodes (left) and functional magnetic resonance imaging (right) to detect a low-frequency brain signal that doesn’t stop, even in sleep.Neuroscientists at the School of Medicine have taken one of the first direct looks at one of the human brain’s most fundamental “foundations”: a brain signal that never switches off and may support many cognitive functions. Their results are an important step forward for efforts to outline what neuroscientists call the functional architecture of the brain. Better understanding of this architecture will aid efforts to treat brain injury and mental disorders.

A protein that helps keep immune cells quiet is more abundant in the spinal fluid of patients with multiple sclerosis (MS), further boosting suspicion that the protein, TREM-2, may be an important contributor to the disease.

Calorie restriction, a diet that is low in calories and high in nutrition, may not be as effective at extending life in people as it is in rodents, according to scientists at the School of Medicine. Previous research had shown that laboratory animals given 30 percent to 50 percent less food can live up to 50 percent longer, but new research suggests the diet may not have the desired effect unless people on calorie restriction also pay attention to their protein intake.

Imran Zoberi, M.D., has been named medical director of radiation oncology at the Siteman Cancer Center at Barnes-Jewish West County Hospital.

Kerri Morgan, instructor in the Program in Occupational Therapy, took fifth place in two events at the 2008 Paralympic Games in Beijing Sept. 11 and 15.

An in-depth study of one-sided or unilateral hearing has now received a five-year, $3 million grant from the National Institutes of Health.

School of Medicine researchers will lead a $10 million multicenter clinical trial of an aggressive treatment for blood clots in the leg known as deep vein thrombosis.

The genome of a humble worm that dines on the microbial organisms covering the carcasses of dead beetles may provide clues to the evolution of parasitic worms, including those that infect humans, say scientists at the School of Medicine and the Max-Planck Institute for Developmental Biology in Germany. In a paper published in the current issue of Nature Genetics, the researchers reported finding some surprises as they have decoded the genome of the worm, a tiny nematode called Pristionchus pacificus.

A new predictive measurement, called a PEPI score, could bring good news to many women diagnosed with advanced breast cancer — a low PEPI (preoperative endocrine prognostic index) score could show that they have little risk of relapse and can safely avoid chemotherapy after surgery. For others, a high PEPI score could warn that the risk of relapse after breast surgery is large and indicate that careful follow-up and aggressive therapy may be needed, say researchers at the School of Medicine.