School of Medicine

Fragile X syndrome, an inherited cause of autism and intellectual disability, can have consequences even for carriers of the disorder who don’t have full-blown symptoms. Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treatment for fragile X carriers.

Washington University in St. Louis kicked off a yearlong initiative, “Gun Violence: A Public Health Crisis,” with a panel discussion April 21 at the Eric P. Newman Education Center.

New research highlights how nerves – whether harmed by disease or traumatic injury – start to die, a discovery that unveils novel targets for developing drugs to slow or halt devastating neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease and amyolateral sclerosis as well as peripheral nerve damage.

Many studies have linked more sleep to better memory, but new research in fruit flies at Washington University School of Medicine in St. Louis demonstrates that extra sleep helps the brain overcome catastrophic neurological defects that otherwise would block memory formation.

An enzyme secreted by the body’s fat tissue controls energy levels in the brain, according to new research led by Shin-ichiro Imai, MD, PhD, of the School of Medicine. The findings, in mice, underscore a role for the body’s fat tissue in controlling the brain’s response to food scarcity, and suggest there is an optimal amount of body fat for maximizing health and longevity.

U.S. Sen. Roy Blunt, R-Mo., visited the Medical Campus this week to meet with physicians who treat patients with Alzheimer’s disease, and patients and caregivers who live with the debilitating disease every day. Blunt, pictured with physician-scientist Randall J. Bateman, chairs a subcommittee that oversees funding for medical research.

Washington University in St. Louis graduate student Andrea Karl found herself thrust into the national spotlight this month at the St. Louis GO! Marathon when an imposter at the finish line denied Karl her first-place accolades. She got to recreate the finish at Busch Stadium. Karl is working towards a PhD in molecular genetics and genomics in the Division of Biology & Biomedical Sciences (DBBS) at the School of Medicine. DBBS is in the Graduate School of Arts & Sciences.

Gretchen Meyer, PhD, an instructor in physical therapy and in neurology at Washington University School of Medicine in St. Louis, has received a $35,000 grant from the university’s Musculoskeletal Research Center for research titled “Promoting Rotator-cuff Muscle Regeneration With Paracrine Adipose Signaling.”

George E. Miles, MD, PhD, a clinical fellow in molecular genetic pathology, in July will become the first Genentech Research Fellow in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis.

Scientists have long suspected that respiratory viruses play a critical role in the development of chronic lung diseases such as asthma and chronic obstructive pulmonary disease (COPD). Studying mouse and cell models of this process, researchers now have shown how immune cells dispatched to the lung to destroy a respiratory virus can fail to disperse after their job is done, setting off a chain of inflammatory events that leads to long-term lung problems.