Probing proteins’ 3-D structures suggests existing drugs may work for many cancers

Probing proteins’ 3-D structures suggests existing drugs may work for many cancers

Examining databases of proteins’ 3-D shapes, scientists at School of Medicine have identified more than 850 DNA mutations that appear to be linked to cancer. The information may expand the number of cancer patients who can benefit from existing drugs. The study, published June 13 in Nature Genetics, detailed a list of the mutations and associated drugs that may work against them.

Barch receives 2016 AWN mentor award

Deanna Barch, chair of the Department of Psychological & Brain Sciences in Arts & Sciences and the Gregory B. Couch Professor of Psychiatry in the School of Medicine, is the 2016 recipient of the mentor award from the Academic Women’s Network at Washington University.
Guilak receives award from Osteoarthritis Research Society

Guilak receives award from Osteoarthritis Research Society

Farshid Guilak, PhD, a professor of orthopaedic surgery at Washington University School of Medicine and director of research at Shriners Hospitals for Children-St. Louis, has received the Basic Science Research Award from the Osteoarthritis Research Society International.
Gut microbes’ metabolite dampens proliferation of intestinal stem cells

Gut microbes’ metabolite dampens proliferation of intestinal stem cells

New research at Washington University School of Medicine in St. Louis indicates stem cells located in “pockets” in the intestine avoid contact with a prominent metabolite produced by beneficial microbes living in the gut. That metabolite – butyrate – restricts the proliferation of stem cells, potentially hampering the intestine from repairing itself after an injury or damage.
Brophy named to orthopaedic surgery board

Brophy named to orthopaedic surgery board

Sports medicine specialist Robert H. Brophy, MD, associate professor of orthopaedic surgery at Washington University School of Medicine in St. Louis, has been elected to the American Academy of Orthopaedic Surgeons board of directors.

Sandell honored by Osteoarthritis Research Society

Linda J. Sandell, the Mildred B. Simon Professor or Orthopaedic Surgery at Washington University School of Medicine in St. Louis, has received the Lifetime Achievement Award from the Osteoarthritis Research Society International.
Development of gut microbes and gut immunity linked

Development of gut microbes and gut immunity linked

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes. The findings have implications for understanding healthy growth and, potentially, the origins of various immune disorders.
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