Gut microbes’ metabolite dampens proliferation of intestinal stem cells

Gut microbes’ metabolite dampens proliferation of intestinal stem cells

New research at Washington University School of Medicine in St. Louis indicates stem cells located in “pockets” in the intestine avoid contact with a prominent metabolite produced by beneficial microbes living in the gut. That metabolite – butyrate – restricts the proliferation of stem cells, potentially hampering the intestine from repairing itself after an injury or damage.
Brophy named to orthopaedic surgery board

Brophy named to orthopaedic surgery board

Sports medicine specialist Robert H. Brophy, MD, associate professor of orthopaedic surgery at Washington University School of Medicine in St. Louis, has been elected to the American Academy of Orthopaedic Surgeons board of directors.

Sandell honored by Osteoarthritis Research Society

Linda J. Sandell, the Mildred B. Simon Professor or Orthopaedic Surgery at Washington University School of Medicine in St. Louis, has received the Lifetime Achievement Award from the Osteoarthritis Research Society International.
Development of gut microbes and gut immunity linked

Development of gut microbes and gut immunity linked

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes. The findings have implications for understanding healthy growth and, potentially, the origins of various immune disorders.
Itching for no reason? Immune system may be at fault

Itching for no reason? Immune system may be at fault

People who suffer itching with no clear cause may have previously unrecognized immune system defects. In a small study of such patients, researchers from the Center for the Study of Itch at Washington University School of Medicine in St. Louis identified immune system irregularities that may prompt the urge to scratch.
As more states legalize marijuana, adolescents’ problems with pot decline

As more states legalize marijuana, adolescents’ problems with pot decline

A survey of more than 216,000 adolescents from all 50 states indicates the number of teens with marijuana-related problems is declining. Similarly, the rates of marijuana use by young people are falling despite the fact more U.S. states are legalizing or decriminalizing marijuana use and the number of adults using the drug has increased. Researchers at the School of Medicine examine the data.
School of Medicine nurses honored

School of Medicine nurses honored

Two School of Medicine nurses have received the 2016 Excellence in Nursing Award from St. Louis Magazine, while six others were finalists. The annual awards, announced in April, honor local nurses who have made a difference in the lives of their patients and colleagues.

Barch, Ley, Boime to be honored

Deanna Barch, a leading researcher on the role of cognition, emotion and brain function in illnesses such as schizophrenia and depression; Irving Boime, a developmental biologist; and Timothy Ley, MD, an expert in cancer genomics and leukemia, will be honored by Washington University in St. Louis, Chancellor Mark S. Wrighton has announced.
View More Stories