New math model of heart cell has novel calcium pathway

David Kilper/WUSTL PhotoProfessor Yoram Rudy (center), with Ph.D. student Yong Wang (left) and post-doctroal fellow Leonid Livshitz (right), with their ECGI system on a mannequin, comment on the cardiac data.Scientists at Washington University in St. Louis have developed the first mathematical model of a canine cardiac cell that incorporates a vital calcium regulatory pathway with implications for life-threatening cardiac arrhythmias, or irregular heartbeats. Thomas J. Hund, Ph.D., post-doctoral researcher in Pathology ( in Dr. Jeffrey Saffitz laboratory) at the Washington University School of Medicine, and Yoram Rudy, The Fred Saigh Distinguished Professor of Engineering at Washington University, have incorporated the Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) regulatory pathway into their model, improving the understanding of the relationship between calcium handling in cardiac cells and the cell’s electrical activity.

Space scientist proposes new model for Jupiter’s core

Jupiter: a core of tar.After eleven months of politics, now it’s time for some real “core values” – not those of the candidates but those of the great gas giant planet, Jupiter. Katharina Lodders, Ph.D., Washington University in St. Louis research associate professor in Earth and Planetary Sciences in Arts & Sciences, studying data from the Galileo probe of Jupiter, proposes a new mechanism by which the planet formed 4.5 billion years ago.

Ground broken for new building to spur biotechnology in St. Louis

Rendering of the new CORTEX buildingEfforts to develop a significant biotechnology industry in St. Louis got a major boost with the groundbreaking for a new laboratory and office building that will provide space for growing companies. The new building at 4300 Forest Park Avenue in midtown St. Louis is being developed by CORTEX, the Center of Research, Technology & Entrepreneurial Exchange.

The value of failure

“Experimental failure is a basic element of university life, and from the university perspective a failed spacecraft is not necessarily a failed mission,” Michael Swartwout said.

Balancing act

Ever since Dora E. Angelaki, Ph.D., left the small Greek island of Crete to attend college, she’s pursued her dream of becoming an academic with what her colleagues agree is one of her most distinguishing features: energy. “Dora is a scientific dynamo, and her boundless energy and enthusiasm are infectious for students and faculty alike,” […]
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