McKelvey School of Engineering

It’s a little like finding out that Superman is actually Clark Kent. A team of biologists at Washington University in St. Louis has discovered that two vital cellular components, nuclear RNA Polymerases IV and V (Pol IV and V), found only in plants, are actually specialized forms of RNA Polymerase II, an essential enzyme of all eukaryotic organisms, including humans.

Joshua Maurer, Ph.D., assistant professor of chemistry in Arts & Sciences at Washington University in St. Louis, has received a four-year, $1,216,000 grant from the National Institute of Mental Health for research titled, “Unraveling Development: New Materials for Understanding Neuronal Wiring.” Maurer’s long term objective is to develop methodology that allows the study of a variety of neuronal wiring processes. He is starting by unscrambling a phenomenon known as midline crossing using zebrafish. During development, neurons from the right eye cross the midline of the brain to make a connection in the left hemisphere.

Washington University is in the spotlight for its pivotal role in the Genomics Education Partnership, a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country.

PikaardA team led by Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences, has made a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. Since the machinery involved in nucleolar dominance is some of the same machinery that can go haywire in diseases such as cancer, Pikaard and his collaborators’ research may have important implications for applied medical research. Click here for a podcast from Genetic Engineering & Biotechnology News: Interview with Craig Pikaard.

Photo by Joe AngelesChancellor Mark S. Wrighton announced during a news conference Dec. 2 the establishment of the Consortium for Clean Coal Utilization.

Washington University Chancellor Mark S. Wrighton announced during a Dec. 2 news conference the establishment of the Consortium for Clean Coal Utilization. The university has dedicated more than $60 million in financial resources during the past year to advance education and research related to energy, environment and sustainability.

A news conference to announce a clean coal initiative with a goal of making St. Louis the nation’s center for clean coal research will be held at 10:30 a.m. on Tuesday, Dec. 2, 2008, at Whitaker Hall on the Washington University Danforth Campus. Chancellor Mark S. Wrighton, along with heads of Peabody Energy, Arch Coal and Ameren, will make the announcement.

ElginWashington University in St. Louis is in the spotlight for its pivotal role in the Genomics Education Partnership, a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country. At the helm of this mission is Sarah C.R. Elgin, Ph.D., WUSTL professor of biology and professor of education in Arts & Sciences, as well as professor of biochemistry & molecular biophysics and professor of genetics in the School of Medicine.

Researchers at Washington University in St. Louis have shed light on a basic process that could improve future solar cells. Dewey Holten, Ph.D., professor of chemistry in Arts & Sciences and graduate student Hee-eun Song have directly measured the rate of hole transfer between identical porphyrin compounds in their ground states. These results are key to understanding the fundamental processes underlying charge separation in this sort of structure and have applications for improving the efficiency of solar cells.

Biologists at Washington University in St. Louis have made major headway in explaining a mechanism by which plant cells silence potentially harmful genes. A team led by Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences, has published a paper this month in Cell, that explains how RNA polymerases work together to use the non-coding region of DNA to prevent destructive, virus-derived genes from being activated.