Researchers solve piece of large-scale gene silencing mystery

PikaardA team led by Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences, has made a breakthrough in understanding the phenomenon of nucleolar dominance, the silencing of an entire parental set of ribosomal RNA genes in a hybrid plant or animal. Since the machinery involved in nucleolar dominance is some of the same machinery that can go haywire in diseases such as cancer, Pikaard and his collaborators’ research may have important implications for applied medical research. Click here for a podcast from Genetic Engineering & Biotechnology News: Interview with Craig Pikaard.

Washington University chancellor, heads of Peabody Energy, Arch Coal and Ameren join global partnership to improve environment

A news conference to announce a clean coal initiative with a goal of making St. Louis the nation’s center for clean coal research will be held at 10:30 a.m. on Tuesday, Dec. 2, 2008, at Whitaker Hall on the Washington University Danforth Campus. Chancellor Mark S. Wrighton, along with heads of Peabody Energy, Arch Coal and Ameren, will make the announcement.

Research-based undergraduate course expands beyond WUSTL

ElginWashington University in St. Louis is in the spotlight for its pivotal role in the Genomics Education Partnership, a collaborative effort to provide research experience in genomics to undergraduate classrooms across the country. At the helm of this mission is Sarah C.R. Elgin, Ph.D., WUSTL professor of biology and professor of education in Arts & Sciences, as well as professor of biochemistry & molecular biophysics and professor of genetics in the School of Medicine.

Precise measurement of phenomenon advances solar cell understanding

Researchers at Washington University in St. Louis have shed light on a basic process that could improve future solar cells. Dewey Holten, Ph.D., professor of chemistry in Arts & Sciences and graduate student Hee-eun Song have directly measured the rate of hole transfer between identical porphyrin compounds in their ground states. These results are key to understanding the fundamental processes underlying charge separation in this sort of structure and have applications for improving the efficiency of solar cells.

New gene silencing pathway found in plants

Biologists at Washington University in St. Louis have made major headway in explaining a mechanism by which plant cells silence potentially harmful genes. A team led by Craig Pikaard, Ph.D., WUSTL professor of biology in Arts & Sciences, has published a paper this month in Cell, that explains how RNA polymerases work together to use the non-coding region of DNA to prevent destructive, virus-derived genes from being activated.

Book on Biblical humor is ‘gospel according to Peters’

To most, the Bible is a somber work, full of such serious melodramas as Abraham intent on carving up his son at God’s demand, Job enduring his many burdensome troubles, and powerful, piercing language, such as the immortal line: Jesus wept. To David A. Peters, Ph.D., McDonnell Douglas Professor of Engineering at Washington University in St. Louis, the Bible indeed is a beautiful work that is sprinkled liberally with, at times, rollicking humor. Peters, whose academic expertise is aeronautics, particularly helicopter mechanics, has written a book, The Many Faces of Biblical Humor (Hamilton Books, 2008) that overwhelmingly backs his claim.

Brain implants may help stroke patients overcome partial paralysis

Scientists have shown for the first time that neuroprosthetic brain implants may be able to help stroke patients with partial paralysis. Researchers found that implants known as brain-computer interfaces (BCI) may be able to detect activity on one side of the brain that is linked to hand and arm movements on the same side of the body. They hope to use these signals to guide motorized assistance mechanisms that restore mobility in partially paralyzed limbs.

Set energy goals and reach them

Wind power is one practical alternative to petroleum.The director of a sustainable energy research center at Washington University in St. Louis is challenging President-elect Barack Obama to set goals in energy research and implementation. “I would like to see the next president of the United States set a similar goal to President Kennedy’s from 1961 — to put a man on the moon and to bring him back to Earth by the end of the decade,” says Himadri B. Pakrasi, Ph.D., the George William and Irene Koechig Freiberg Professor of Biology in Arts & Sciences, and Professor of Energy in the School of Engineering and Applied Science.
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