Deep genomics: Scientists probe the epigenome

A Washington University in St. Louis team is participating in the modENCODE project, a massive ongoing effort to map all the elements in model organisms that affect whether genes are silenced or expressed. The work supports the more complex ENCODE project, which is tasked to map the same elements in the human genome. While the genome is the same in every cell, each cell type expresses a different set of genes. In people, moreover, roughly 95 percent of the genome is silenced. Together the projects will “put flesh on the bones” of the Human Genome Project, says team leader Sarah C.R. Elgin.

New method takes snapshots of proteins as they fold

Using a sophisticated version of the stroboscopic photography a pioneering photographer used in 1877 to prove that a horse takes all four hooves off the ground when it gallops, Michael L. Gross, PhD, professor of chemistry in Arts & Sciences and of medicine and immunology in the School of Medicine, catches proteins in the act of folding.

A moveable feast

In 1890, the American painter John La Farge embarked on a yearlong journey through the islands of the South Pacific. Just months later, Paul Gauguin began his own Polynesian odyssey. Though the two artists never met, their paths nearly crossed in Tahiti, with Gauguin arriving a mere four days after La Farge departed. So it is perhaps fitting that, last fall, a group of five graduate and undergraduate students from the Department of Art History and Archaeology in Arts & Sciences set out on their own mission of travel, visiting a pair of East Coast exhibition that focused on works by the two artists. 

Reporter’s guide to filibuster reform in the U.S. Senate

Reporters covering the Senate and citizens watching from the sidelines will welcome a new guide to the upcoming battle over the filibuster from one of the preeminent authorities on Congress.  Political science professor Steven S. Smith has prepared a primer outlining proposals and procedures for reforming the Senate’s rules pertaining to filibusters. Get ready for the opening of the 112th Congress and a possible showdown over the parliamentary procedure that has been used to block legislation by both parties and famously by Jimmy Stewart in the 1939 film, Mr. Smith Goes to Washington.
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