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Medicine & Health

Clot-busting drugs not recommended for most patients with blood clots

About half of people with blood clots in the deep veins of their legs develop a complication that involves chronic limb pain and swelling, making it difficult for some to walk and perform daily activities. A large-scale clinical trial has shown that a risky, costly procedure to remove such clots fails to reduce the likelihood that patients will develop the debilitating complication.

Oltz named editor-in-chief of immunology journal

Oltz
The American Association of Immunologists (AAI) has named Eugene M. Oltz the next editor-in-chief of The Journal of Immunology. Oltz is professor and the vice chair for faculty development in the Department of Pathology and Immunology at Washington University School of Medicine in St. Louis.
Science & Technology

Uncovering the design principles of cellular compartments

Membraneless organelles are tiny droplets inside a single cell, thought to regulate everything from division, to movement, to its very destruction. New research from engineers at Washington University in St. Louis uncovers the principles underlying the formation and organization of membraneless organelles.
Medicine & Health

Obesity prevented in mice fed high-fat diet

Researchers at Washington University School of Medicine in St. Louis have identified a way to prevent fat cells from growing larger, a process that leads to weight gain and obesity. By activating a pathway in fat cells in mice, the researchers found they could feed the animals a high-fat diet without making them obese.
Medicine

Pursuing a precision paradigm

Dean David Perlmutter, MD, is aligning resources at the School of Medicine to focus on ­personalized, precision ­medicine: managing health ­instead of disease, providing the right ­treatment for the right patient, and developing drugs and other ­therapies faster and at lower cost.
Why move from current standards of patient care to a more personalized approach to treatment? Experts at the School of Medicine describe today’s medical landscape as they plan for the care — and cures — of the future.
Medicine

Building the foundation for discovery

The School of Medicine is building the necessary infrastructure through centers and institutes to allow research that is more efficient and cost-effective, and that encourages high risks leading possibly to key breakthroughs.
Medicine

Undaunted explorer

Timothy Ley, MD, the Lewis T. and Rosalind B. Apple Professor of Medicine, is a hematologist, oncologist and cancer biologist. For decades, the Ley lab has used mouse models of acute myeloid leukemia to establish key principles of AML pathogenesis. (Photo: James Byard)
Timothy Ley, MD, has been investigating leukemia, particularly acute myeloid leukemia (AML), for decades. His research team now knows the mutations they need to go after ­aggressively, the nature of the ­mutations that need to be targeted and why patients relapse.