Fat in the liver — not the belly — is a better marker for disease risk

New findings from nutrition researchers at the School of Medicine suggest that it’s not whether body fat is stored in the belly that affects metabolic risk factors for diabetes, high blood triglycerides and cardiovascular disease, but whether it collects in the liver. They report online in the journal PNAS Early Edition that when fat collects in the liver, people experience serious metabolic problems such as insulin resistance, which affects the body’s ability to metabolize sugar.

Research shows why low vitamin D raises heart disease risks in diabetics

Low levels of vitamin D are known to nearly double the risk of cardiovascular disease in patients with diabetes, and now researchers at the School of Medicine think they know why. They have found that diabetics deficient in vitamin D can’t process cholesterol normally, so it builds up in their blood vessels, increasing the risk of heart attack and stroke.

Cambodians unsure tribunals will heal wounds of mass killings, JAMA study suggests

These skulls, from victims of the Khmer Rouge, are on display in a Buddhist stupa at Choeung Ek, a mass burial site commonly known as one of “the killing fields.”Lessons learned from research into the societal effects of post-Apartheid “truth and reconciliation” hearings in South Africa are now being applied to a U.S. National Institute of Peace-sponsored study of the long-term mental health impact on Cambodians from human rights tribunals targeting the killing of millions by the nation’s former Khmer Rouge regime, says James L. Gibson, a professor of political science at Washington University in St. Louis and co-author of a study published Aug. 6 in the Journal of the American Medical Association (JAMA).

Metabolic City at Mildred Lane Kemper Art Museum Sept. 18 to Jan. 4, 2010

Amidst the cultural and political ferment of the 1960s, avant-garde artists and architects began embracing biological and scientific models as well as the potentials of emerging technologies to explore radical new directions in urban design, developing projects that were at once fanciful, complex and conceptually serious. This fall the Mildred Lane Kemper Art Museum will present Metabolic City, an exhibition surveying work by the British collective Archigram; the Japanese Metabolists (whose members include Fumihiko Maki, architect of the Kemper Art Museum); and the Dutch painter Constant Nieuwenhuys, an early member of the Situationist International.

MO Budget Project press conference Aug. 20

On Thursday, August 20th, business, faith and health care leaders from across the region will come together at the Family Care Health Center in St. Louis to give their perspective on why federal health care reform is important for Missouri. The speakers, including health care providers, educators, business owners and faith leaders, will each speak for several minutes and then make themselves available to answer media questions following the presentations.

Low-dose estrogen shown safe and effective for metastatic breast cancer

When estrogen-lowering drugs no longer control metastatic breast cancer, the opposite strategy might work. Raising estrogen levels benefited 30 percent of women whose metastatic breast cancer no longer responded to standard anti-estrogen treatment, according to research conducted at the School of Medicine and collaborating institutions.

Scientists identify cells in fruit fly gut that start tumors

Tumor growth can start from stem cells in the gut, say researchers studying fruit flies at the School of Medicine. They found that tumors can grow from adult stem cells that have lost a specific tumor-suppressor gene. The gene, Apc, has previously been implicated in human gastrointestinal cancers, including colon cancer.

Youth with autism coming of age: Brown School study will focus on transitions in service use and coverage

For teens with autism spectrum disorders (ASD) and their families, the transition to young adulthood may be especially difficult. To better understand this issue and how best to address it, the National Institute of Mental Health (NIMH) has awarded a five-year grant to Paul T. Shattuck, Ph.D., assistant professor at the George Warren Brown School of Social Work at Washington University in St. Louis. “This study will help us one day answer one of the most pressing issues in treating ASD,” said NIMH Director Thomas R. Insel, M.D. “Bridging the gap in health care, service use, and insurance coverage as these young people leave the school systems and enter adulthood may help prevent lapses in behavioral, social, and occupational skills that they and their families have worked so hard to achieve.”