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WUSM scientists have identified a protein that helps keep internal “clocks” in sync.Scientists have identified a receptor protein that helps the fruit fly know when to start and shut down its day. Neuroscientists from the School of Medicine identified a receptor for pigment-dispersing factor (PDF) protein, which scientists previously recognized as a molecule that helps keep different internal “clocks” synchronized. Because these timekeeping processes have been highly conserved through evolution, what the scientists learn from flies and other organisms may help them better understand the same systems in humans.

Sustiva is the brand name for efavirenz.The largest detailed, prospective clinical study of the mental side effects of a potent anti-AIDS drug, efavirenz, has revealed that the anxiety, dizziness, “funny feelings” and vivid dreams triggered by the drug fade away within a month, possibly clearing the way for more widespread use. Efavirenz is the first drug from its class that lasts long enough to be taken once a day, and that makes it a potentially valuable drug for AIDS treatment.

Bright areas in this image highlight the junctions between heart muscle cells.Failing hearts develop interference in their communication channels, according to research conducted at the School of Medicine. The problem involves a subtle change in the pores that connect heart muscle cells. When the scientists duplicated this change in mice, the mice became susceptible to ventricular tachycardia, a dangerous heart rhythm disorder that can lead to sudden cardiac death.

Since the Office of Supplier Diversity was started in 1999, WUSTL has spent $85 million with minority-owned firms and $77 million with women-owned firms.

Such programs at the very least “need to consider the traditional foods and recipes of the participants,” said lead author James Herbert Williams.

Photo by Robert BostonHelping kick off St. Louis Children’s Hospital’s “Building for Care, Searching for Cures” campaign were Joe Buck, Jonathan D. Gitlin, Lee Fetter and Larry Shapiro.The collaboration will focus on accelerating cures in four areas: congenital heart disease, cancer, lung and respiratory disorders and musculoskeletal diseases. More medical news

Warfarin, also known by the brand name Coumadin, is often given to patients with atrial fibrillation, irregular contractions of the upper chambers of the heart.

Jacob Schaefer, Ph.D., Karen L. Wooley, Ph.D., Luis H. Zayas, Ph.D., Kenneth Harrington, Li Mei Chen, Ph.D., and more…

Surgeons once treated blockages with a carotid bypass, which reroutes a scalp artery to restore normal brain blood flow and pressure.

At recent Board of Trustees meetings, faculty members were granted tenure, promoted with tenure, appointed with tenure or granted a track change with tenure.