Science & Technology

Michael R. Brent and Tamara L. Doering examine data from the *C. neoformans* microarray.A team of collaborators, including two researchers from Washington University in St. Louis, has sequenced the genomes of two strains of the fungus Cryptococcus neoformans (C. neoformans), one which is virulent, the other harmless. This work provides researchers with clues on how the fungus does its dirty work and a host of genes to study for a better understanding of fungal pathogens in general. Estimates are that about 15 percent of people with HIV will suffer at least one life-threatening infection of C. neoformans. In Africa, that could be as much as 40 percent of HIV sufferers.

Christine Floss, Ph.D., and Frank Stadermann, Ph.D., examine data on the NanoSIMS in Compton Hall.A collaborative team of researchers including two from WUSTL have discovered what turns the lights out from space. They have discovered that organic carbon and amorphous silicates in interstellar grains embedded within interplanetary dust particles (IDPs) are the carriers of the astronomical 2175 Å extinction line, which occurs at a wavelength of 2175 Angstroms and blocks starlight from reaching the Earth.

*Arabidopsis thaliana*A team headed by Craig Pikaard, Ph.D., Washington University professor of biology in Arts & Sciences, has discovered a fourth kind of RNA polymerase found only in plants and speculated to have been a plant feature for more than 200 million years.

In his talk, Murray Gell-Mann will look back to 1905 when Albert Einstein, an unknown scientist, published several papers, each with a revolutionary idea. He will examine Einstein’s creative thinking, how current cosmological discoveries relate to his work, and today’s efforts to find a unified theory of everything. Gell-Mann received the Nobel Prize in physics in 1969 for his discovery of the quark – the basic building block of all atomic nuclei throughout the universe.

A first-of-its-kind application of a novel statistical method of analysis to African Americans has identified regions on chromosomes 6 and 21 that likely harbor genes contributing to high blood pressure in that group. The novel statistical method, called admixture mapping, narrowed the search for genes related to hypertension, bringing researchers and doctors closer to finding more effective treatments.

JostR. Gilbert Jost, M.D., the Elizabeth Mallinckrodt Professor and head of Radiology at the School of Medicine, has been named chairman of the board of directors of the Radiological Society of North America (RSNA). The society is an organization of more than 37,000 radiologists, radiation oncologists and related scientists.

Kurt Gottfried, co-founder and chair of the Union of Concerned Scientists (UCS), has made scientific advocacy his vocation and is committed to generating independent scientific advice for use in creating public policies that affect Americans’ lives. Gottfried will present the William C. Ferguson Lecture, “Science Meets Politics: From Thomas Jefferson to George W. Bush,” at […]

David Kilper / WUSTL PhotoWUSTL researchers are trying to infer the Egyptian climate from the fossil evidence.Earth and planetary scientists at Washington University in St. Louis are studying snail fossils to understand the climate of northern Africa 130,000 years ago. While that might sound a bit like relying on wooly bear caterpillars to predict the severity of winter, the snails actually reveal clues about the climate and environment of western Egypt, lo those many years ago. They also could shed light on the possible role weather and climate played in the dispersal of humans “out of Africa” and into Europe and Asia.

Carrine Blank/WUSTL PhotoA WUSTL scientist suggests that Cyanobacteria arose in freshwater environments rather than in the sea.A geomicrobiologist at Washington University in St. Louis has proposed that evolution is the primary driving force in the early Earth’s development rather than physical processes, such as plate tectonics. Carrine Blank, Ph.D., Washington University assistant professor of geomicrobiology in the Department of Earth & Planetary Sciences in Arts & Sciences, studying Cyanobacteria – bacteria that use light, water, and carbon dioxide to produce oxygen and biomass – has concluded that these species got their start on Earth in freshwater systems on continents and gradually evolved to exist in brackish water environments, then higher salt ones, marine and hyper saline (salt crust) environments.

David Kilper/WUSTL PhotoProfessor Yoram Rudy (center), with Ph.D. student Yong Wang (left) and post-doctroal fellow Leonid Livshitz (right), with their ECGI system on a mannequin, comment on the cardiac data.Scientists at Washington University in St. Louis have developed the first mathematical model of a canine cardiac cell that incorporates a vital calcium regulatory pathway with implications for life-threatening cardiac arrhythmias, or irregular heartbeats. Thomas J. Hund, Ph.D., post-doctoral researcher in Pathology ( in Dr. Jeffrey Saffitz laboratory) at the Washington University School of Medicine, and Yoram Rudy, The Fred Saigh Distinguished Professor of Engineering at Washington University, have incorporated the Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) regulatory pathway into their model, improving the understanding of the relationship between calcium handling in cardiac cells and the cell’s electrical activity.