Science & Technology

Mouse embryos stained to show MOF (green) and its histone tag (red) demonstrate that MOF is essential for cell proliferation.To make tumors more sensitive to the killing power of radiation is a key aspiration for many radiation oncologists. Researchers at the School of Medicine have uncovered new information that leads them closer to that goal. In an upcoming issue of the journal Molecular and Cellular Biology, they report the first extensive study of an enzyme called MOF that helps control how DNA is packaged in cells. The researchers show that MOF is an essential factor for tumor development, and they say it may be possible to manipulate the enzyme to make tumors more sensitive to radiation therapy.

As reservoirs of valuable information go, nothing beats the sun. This sphere of heat and energy holds 99.9 percent of the solar system, saved in all original proportions after planets and meteorites formed. Analyzing the mix of hydrogen, oxygen and noble gases found in the sun can answer one of the biggest questions of the universe: How did our solar system evolve? Scientists at Washington University in St. Louis and a large team of colleagues marked the beginnings of that odyssey by examining samples of solar wind for neon and argon, two abundant noble gases. The work was published in the Oct. 19, 2007, issue of Science.

WUSTL researcher Stanton Braude, Ph. D., lecturer in biology in Arts & Sciences, says the secret to a long life in humans might exist in the wrinkled body of one of the world’s ugliest animals — the naked mole rat.

Washington University researcher Stanton Braude, lecturer in biology in Arts & Sciences, says the secret to a long life in humans might exist in the wrinkled body of one of the world’s ugliest animals — the naked mole rat.

WUSTL senior Ruth Poland and Jonathan Chase, Ph.D., associate professor of biology and director of WUSTL’s Tyson Research Center, check species out in one of Tyson’s ponds.An ecologist at Washington University in St. Louis has discovered that after ponds dry up through drought in a region, when they revive, the community of species in each pond tends to be very similar to one another in species composition.

Photo by David KilperThat clover necklace you make for your child could be a ring of poison. That’s because some clovers have evolved genes that help the plant produce cyanide — to protect itself against herbivores such as snails, slugs and voles. Kenneth Olsen, Ph.D., assistant professor of biology in Arts & Sciences, is looking at the genetics of a wide variety of white clover plants to determine why some plants do and some plants don’t make cyanide. Ecology and geography play important roles.

Is that clover necklace you make for your child poison? It could be. Kenneth Olsen, Ph.D., Washington University assistant professor of biology in Arts & Sciences, is looking at the genetics of a wide variety of white clover plants to determine why some plants do and some plants don’t make cyanide. Ecology and geography play important roles.

Photo by David KilperLarry A.Taber, Ph.D., (left) the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, employ a microindentation device to measure the mechanical properties of embryonic hearts and brains. The researchers are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and more intellectual capacity) than a brain of comparable volume with a smooth surface.

Image courtesy of the BBCWhat good is longevity if you end up looking like this? WUSTL biologist Stan Braude, working on a book about the critters, says the naked mole rat is being studied for its tendency to live a long life.Who would have thought that the secrets to long life might exist in the naked, wrinkled body of one of the world’s ugliest animals? Probably not many, but current research may be leading seekers of the Fountain of Youth to a strange little beast — the naked mole rat.

Engineers at Washington University in St. Louis are finding common ground between the shaping of the brain and the heart during embryonic development. Larry A.Taber, Ph.D., the Dennis and Barbara Kessler Professor of Biomedical Engineering, and Philip Bayly, Ph.D., the Hughes Professor of Mechanical Engineering, are examining mechanical and developmental processes that occur in the folding of the brain’s surface, or cortex, which gives the higher mammalian brain more surface area (and hence more intellectual capacity) than a brain of comparable volume with a smooth surface.