Current technology for brain cooling unlikely to help trauma patients

Constant blood flow shields the brain from cold, limiting the effects of any attempt to cool the brain.Attempts to cool the brain to reduce injury from stroke and other head trauma may face a significant obstacle: current cooling devices can’t penetrate very deeply into the brain. Scientists at Washington University School of Medicine in St. Louis have shown that blood flow in the brain creates a “cold shielding” effect and have developed a method for calculating brain temperature that may be used to improve brain cooling techniques.

Engineer designs system to put wastewater to work

David Kilper / WUSTL PhotoLars Angenent with an earlier model of his microbial fuel cell. An advance in the design has increased the power output by a factor of 10. Hopes are that the fuel cell can be scaled up even more and function as a viable energy form.In the midst of the worldwide energy crisis, researchers at Washington University in St. Louis have been continuing their work on a microbial fuel cell that generates electricity from wastewater. Advances in the design of this fuel cell in the last year have increased the power output by a factor of 10 and future designs, already in the minds of the researchers, hope to multiply that power output by 10 times again. If that goal can be achieved, the fuel cell could be scaled up for use in food and agricultural industries to generate electrical power – all with the wastewater that today goes right down the drain.

Researcher gives hard thoughts on soft inheritance

Richards has observed the inheritance of epigenetic factors in plants.Eric Richards, Ph.D., professor of biology at Washington University in St. Louis, writing in the May issue of Nature Reviews Genetics, analyzes recent and past research in epigenetics and the history of evolution and proposes that epigenetics should be considered a form of soft inheritance, citing examples in both the plant and mammalian kingdoms.

Nanotechnology enables low-dose treatment of atherosclerotic plaques

These before (left) and after images show the effects of fumagillin-laden nanoparticles in a rabbit aorta.In laboratory tests, one very low dose of a drug was enough to show an effect on notoriously tenacious artery-clogging plaques. But it wasn’t so much the drug itself as how it was delivered. Fumagillin — a drug that can inhibit the growth of new blood vessels that feed atherosclerotic plaques — was sent directly to the base of plaques by microscopically small spheres called nanoparticles.

Triple threat polymer captures and releases

David Kilper/WUSTL PhotoKaren L. Wooley and lab members examine polymer samples.A chemist at Washington University in St. Louis has developed a remarkable nanostructured material that can repel pests, sweeten the air, and some day might even be used as a timed drug delivery system — as a nasal spray, for instance. Karen L. Wooley, Ph.D., Washington University James S. McDonnell Distinguished University Professor in Arts & Sciences, has taken the same materials that she developed more than four years ago as marine “antifouling” coatings that inhibit marine organisms such as barnacles from attaching to the hull of ships to now capture fragrance molecules and release them at room temperature. More…

Mathematician pens book about famous mathematician foibles and funnies

Steven G. Krantz, Ph.D., professor of mathematics at Washington University in St. Louis, illuminates mathematicians’ very human brilliance in his book, Mathematical Apocrypha Redux, his sequel to his successful, original Mathematical Apocrypha, published in 2002, both by the Mathematical Association of America. The book is a collection of anecdotes about famous mathematicians and their frivolity, wisdom and situations, revealing more vulnerable, human versions of the remote and often eccentric savants. More…

Round tables address IT problems, infrastructure, workplace concerns over flu pandemic

Temperature is rising as St. Louis tackles the ramifications of a flu epidemic.St. Louis is one of the few cities trying to stay ahead of the pandemic curve, thanks to workshops being conducted this spring and summer that bring together area institutions and businesses in round table formats. The Business Community and Pandemic Flu Roundtable is sponsored by the Washington University School of Engineering and Applied Science’s Center for the Application of Information Technology (CAIT) and the University’s School of Medicine. CAIT is St. Louis’ center for IT training, professional development, and executive interaction for more than 25 years. More than 100 business and institutional attendees are learning to address everything from potential vaccines and medications to sick leave policy and protective gear. More…
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