Deep genomics: Scientists probe the epigenome

A Washington University in St. Louis team is participating in the modENCODE project, a massive ongoing effort to map all the elements in model organisms that affect whether genes are silenced or expressed. The work supports the more complex ENCODE project, which is tasked to map the same elements in the human genome. While the genome is the same in every cell, each cell type expresses a different set of genes. In people, moreover, roughly 95 percent of the genome is silenced. Together the projects will “put flesh on the bones” of the Human Genome Project, says team leader Sarah C.R. Elgin.

New method takes snapshots of proteins as they fold

Using a sophisticated version of the stroboscopic photography a pioneering photographer used in 1877 to prove that a horse takes all four hooves off the ground when it gallops, Michael L. Gross, PhD, professor of chemistry in Arts & Sciences and of medicine and immunology in the School of Medicine, catches proteins in the act of folding.

BattleBots Battle Royale

Mechanical engineering students maneuver BattleBots during a Battle Royale held Tuesday, Dec. 14. The battle was the final assignment in a freshman mechanical engineering class taught by Pat Harkins, a technical lab technician in the School of Engineering & Applied Science.

Cornstarch might have ended the Gulf spill agony sooner

Last year’s attempt to kill the Macondo well in the Gulf of Mexico by pouring heavy mud down the well bore may have been defeated by an instability that led to turbulent mixing of the oil and the mud. Jonathan Katz, PhD, professor of physics at Washington University in St. Louis, had suggested a simple solution to the problem: cornstarch. Experiments described in an article published recently in Physical Review Letters suggest his solution might have worked.

Champion hydrogen-producing microbe

The cyanobacteria are famous for releasing the oxygen that made the Earth a hospitable planet, but some strains also have a hidden talent for producing hydrogen gas, a potential biofuel. With the help of a few metabolic tricks, a lab at Washington University has coaxed one such strain to produce champion levels of the gas.

How Iapetus, Saturn’s outermost moon, got its ridge

A team of scientists a team, including William B. McKinnon, PhD, professor of earth and planetary sciences in Arts & Sciences at Washington University in St. Louis, propose an explanation for the bizarre ridge belting Saturn’s outermost moon Iapetus. At one time Iapetus itself may have had a satellite, created by a giant impact with another body. The satellite’s orbit would have decayed because of tidal interactions with Iapetus, and at some point it would have been ripped apart, forming a ring of debris around Iapetus that would eventually slam into the moon near its equator,
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