Medicine & Health

A new technique in development will produce quick and efficient radiation dosing.Researchers at Washington University in St. Louis have developed a technique that makes radiation oncologists significantly faster at calculating radiation dosages for patients undergoing cancer treatment. The technique also provides a more carefully controlled dosage of radiation to cancerous cells that is less likely to damage nearby healthy tissues. The research team — led by Victor Wickerhauser, Ph.D., professor of mathematics in Arts & Sciences and Joseph O. Deasy, Ph.D., assistant professor of radiation oncology at the School of Medicine — has turned to a mathematical tool called wavelet analysis to calculate radiation dose distributions. The tool has helped speed up the dose calculations by a factor of two or more compared to the standard dose calculation technique.

Richard CholeInfection of the tonsils, or tonsillitis, is one of the most common infectious diseases of childhood. More than 400,000 tonsillectomies are performed annually in the U.S., making it one of the most common surgical procedures involving children. Prior to surgery, pediatricians prescribe antibiotics, and children get better, but infections can return in a pattern that repeats itself until the doctor — or the frustrated parents — finally decide that the tonsils must come out. Now researchers, led by Richard A. Chole, M.D., Ph.D., Lindburg Professor and head of the Department of Otolaryngology at Washington University School of Medicine in St. Louis, have discovered that bacteria often form biofilms in the wet and warm folds of the tonsils, and that these may serve as reservoirs of repeated infection. Recent evidence has linked biofilms to a variety of persistent infections.

September Medical Science & Health Tip Sheet

WrightIt’s common knowledge that minor aches and pains can be treated by applying cold or heat, but knowing how and when to use these treatments can be tricky, according to Rick W. Wright, M.D., instructor of orthopaedic surgery and sports medicine physician at Washington University School of Medicine in St. Louis. Wright, who serves as a team physician for the several St. Louis area professional sports teams, offers some advice on proper use of hot and cold therapies in an article published recently in the St. Louis Post-Dispatch.

The human brainThe failing memories of older adults, including their tendency to remember things that never happened, are not an inevitable consequence of aging, according to Washington University research presented Aug. 8 at the American Psychological Association meeting in Toronto. The study offers evidence that false memories and other cognitive declines often associated with normal aging can be more directly linked to measurable declines in executive control functions in frontal brain lobes.

Photo by David Kilper/WUSTL PhotoErik Herzog, Ph.D., and graduate student Rachel Huckfeldt attach electrodes to a multielectrode array.Getting over jet lag may be as simple as changing the temperature —your brain temperature, that is. That’s a theory proposed by Erik Herzog, Ph.D. assistant professor of biology in Arts & Sciences at Washington University in St. Louis. Herzog has found that the biological clocks of rats and mice respond directly to temperature changes.

Carrying backpacks the right wayAs parents and kids make their lists for the August back-to-school sales, one item to consider should be a backpack — on wheels, says Nancy J. Bloom, Ph.D., a physical therapy instructor at Washington University School of Medicine in St. Louis. Kids backs are primarily bearing the weight of their schoolbooks. Bloom says that because young bones are growing all the way through high school, heavy backpacks need to be a major concern. She notes that there are a few important things that kids can do to avoid injury, including carrying their backpacks over both shoulders to balance the load.

Cells afflicted with SARS.Rapid and accurate diagnosis is critical for providing optimum care for patients with SARS and for helping contain the disease and protecting the community. If someone with a severe respiratory illness comes to Barnes-Jewish Hospital or St. Louis Children’s Hospital, emergency department physicians now should be able to tell whether the disease is SARS within a few hours. A team of researchers, led by Michael J. Holtzman, M.D., the Selma and Herman Seldin Professor of Medicine and professor of cell biology and physiology at Washington University School of Medicine in St. Louis, developed a diagnostic tool that allows for quick identification of whether a person with respiratory disease has SARS. They also can determine the severity of the infection, and the test can detect the SARS virus even if very few virus molecules make it into the test sample.

Sometimes two shots are better than one. Washington University pediatrician, Robert M. Kennedy, M.D., professor of pediatrics, and other Emergency Department researchers at St. Louis Children’s Hospital, have developed an “ouchless” IV technique. Before inserting a big IV needle into the hand of a child, the physicians first apply numbing gel. Then, they use a tiny needle to inject a local anesthetic into the area before they finally introduce the bigger IV needle. By the time an IV is started, the injection site is numb, and patients who already are in an emergency department, don’t have to face even more pain.

Sophisticated brain imaging reveals that several brain regions can become overactivated when people with Tourette Syndrome perform tasks related to memory.Neuroscience researchers at Washington University School of Medicine in St. Louis are studying the brains of patients with Tourette Syndrome (TS) to see whether they can use sophisticated imaging techniques to identify differences in the dopamine system of people with the tics that characterize TS. A team of researchers, led by Kevin J. Black, M.D., assistant professor of psychiatry, neurology and radiology at Washington University School of Medicine, is using PET imaging to see what the brain does in response to levodopa, a natural amino acid that has been used for many years to treat movement disorders, such as Parkinson’s disease. With PET imaging, the researchers can measure the boost in the brain’s dopamine levels in response to the drug both in people with Tourette Syndrome and in those who do not have tics. By identifying differences, they hope to isolate the causes of tics and to help people with TS control or eliminate them.