Medicine & Health

Severe calorie restriction prevents certain aging-related changes in the brain, including the accumulation of free radicals and impairments in coordination and strength, according to a WUSM mouse study. However, the dietary changes did not seem to prevent mice from developing some cognitive deficits associated with age, such as declines in memory.

High levels of a protein called LRP6 can make cancer cells more aggressive, according to Washington University researchers affiliated with the Siteman Cancer Center. The protein’s ability to enhance tumor development suggests that the gene that codes for LRP6 is an oncogene — a gene that contributes to tumor development when overactivated.

Researchers at Washington University School of Medicine and the University of Pennsylvania have found an immune system cell can “remember” a parasite’s attack and help the body mount a more effective defense against subsequent invasions by the same parasite.

National experts addressed the most pressing political issues in health care at the Oct. 7 “Health Care Challenges Facing the Nation” conference at the Washington University Medical Center. Prominent among the bevy of hot topics were discussions about limiting access to health care to help alleviate rapidly escalating health care costs. Read more in the following St. Louis Post-Dispatch article by Rachel Melcer.

Researchers at the School of Medicine and colleagues in the International Human Genome Sequencing Project have published their scientific description of the finished human genome, reducing the estimated number of human genes from 35,000 to only 20,000-25,000, a surprisingly low number for our species.

EberleinTimothy J. Eberlein has been elected to the National Academy of Sciences’ Institute of Medicine, one of the highest honors medical scientists in the United States can receive. He was selected in recognition of his professional achievements in medical science and health care and leadership in issues affecting public health.

Investigators at the School of Medicine are launching several projects aimed at preventing the global spread of HIV infection by reducing high-risk behaviors in vulnerable populations, including women and youth. These projects build upon work that has been ongoing since 1989.

A minimally invasive approach to curing the most common heart rhythm abnormality, atrial fibrillation, takes half the time of the traditional surgical procedure but is equally effective, according to research at the School of Medicine.

Researchers at Washington University School of Medicine in St. Louis are seeking inner-city children and adolescents for a national asthma study. General asthma rates have been steadily rising, but the most dramatic increases have occurred among urban youth.

Is depression rooted in our genes?Researchers at the School of Medicine are recruiting volunteers as part of an international study designed to uncover the genetic basis of major depression. Identification of susceptibility genes could revolutionize the current understanding of the disease and guide the design of new drugs to prevent or treat this debilitating disorder.