Disabling gene defuses rheumatoid arthritis in mice

Scientists studying mice have identified a gene that allows immune cells known as neutrophils to protect themselves from the inflammatory chemicals they secrete. Researchers at the School of Medicine showed that knocking the gene out in mice prevented the development of an arthritis-like disorder by making the neutrophils victims of their own damaging secretions.

Mortality rates higher from lack of medicine, not managed care

The urban legends about managed care convey a sense that managed care often leads to early death. However, the business methods employed by managed care frequently result in reduced cost for the companies and the individuals enrolled in the programs. Because of the potential savings, the trend has been to encourage Medicare enrollees to use managed care programs. A recent study by a professor in the business school Washington University in St. Louis and a colleague suggests that it’s not managed care that increases mortality; it’s lack of drug coverage. The study suggests that a one percent increase in the number of people enrolled in Medicare Managed Care without drug coverage would result in an additional 5,100 deaths among the elderly population of the United States in one year.

Researchers closing in on the genetic structure of autism and related disorders

Drawing by an autistic childA research team at Washington University School of Medicine in St. Louis has identified regions of DNA that may be related to risk for autism. The researchers are learning how autism is inherited, and to identify genetic factors, they’re studying families and looking for traits that normally aren’t considered autistic but have connections to autism risk. Several studies have demonstrated that autism has a strong genetic component. If one child in a family is autistic, there’s about a 10 percent chance that a sibling also will have autism.
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