Medicine & Health

With the first wave of baby boomers preparing for retirement, the 2005 White House Conference on Aging (WHCOA) will be an important opportunity to assess aging in America and improve the lives of older Americans. St. Louis will play a significant role in shaping the discussion at the conference through “Maximizing Civic Engagement of Older Adults,” a public forum and official WHCOA event hosted by the George Warren Brown School of Social Work and the Center for Aging at Washington University 9 a.m. Feb. 15 in Brown Lounge.

A first-of-its-kind application of a novel statistical method of analysis to African Americans has identified regions on chromosomes 6 and 21 that likely harbor genes contributing to high blood pressure in that group. The novel statistical method, called admixture mapping, narrowed the search for genes related to hypertension, bringing researchers and doctors closer to finding more effective treatments.

Early treatment is key with Down syndrome.Down syndrome is caused by an extra copy of chromosome 21, and its occurence is random 95 percent of the time. The condition can be detected during pregnancy, and intervention during infancy can greatly improve outcomes for children with Down syndrome. Learn more about this condition, which affects 350,000 Americans, in the following St. Louis Post-Dispatch article by WUSM pediatrician Kathy Grange.

A new study has shown a stroke-prevention drug designed to be an improvement over prior treatments is less cost-effective for most patients than warfarin, the blood thinner with a 50-year history of helping prevent blood clots and strokes. The study, conducted by researchers at the School of Medicine found, however, that the new drug would be cost-effective for those atrial fibrillation patients whose risk of bleeding is high.

Research on alcoholism and disorders that tend to occur with it will be presented by national experts at the fifth annual Guze Symposium on Alcoholism. The symposium is dedicated to the late Samuel B. Guze, M.D., a pioneer in alcoholism research, who served 18 years as vice chancellor for medical affairs and president of the Washington University Medical Center.

JostR. Gilbert Jost, M.D., the Elizabeth Mallinckrodt Professor and head of Radiology at the School of Medicine, has been named chairman of the board of directors of the Radiological Society of North America (RSNA). The society is an organization of more than 37,000 radiologists, radiation oncologists and related scientists.

Listed below are this month’s featured news stories. • Is field turf safe? (week of Feb. 2) • Heart surgery and depression (week of Feb. 9) • Reversing Alzheimer’s in mice (week of Feb. 16) • Age affects cervical cancer treatments (week of Feb. 23)

David Kilper/WUSTL PhotoProfessor Yoram Rudy (center), with Ph.D. student Yong Wang (left) and post-doctroal fellow Leonid Livshitz (right), with their ECGI system on a mannequin, comment on the cardiac data.Scientists at Washington University in St. Louis have developed the first mathematical model of a canine cardiac cell that incorporates a vital calcium regulatory pathway with implications for life-threatening cardiac arrhythmias, or irregular heartbeats. Thomas J. Hund, Ph.D., post-doctoral researcher in Pathology ( in Dr. Jeffrey Saffitz laboratory) at the Washington University School of Medicine, and Yoram Rudy, The Fred Saigh Distinguished Professor of Engineering at Washington University, have incorporated the Calcium/Calmodulin-dependent Protein Kinase II (CaMKII) regulatory pathway into their model, improving the understanding of the relationship between calcium handling in cardiac cells and the cell’s electrical activity.

About nineteen percent of people have a genetic variation that may increase susceptibility to osteoporosis, a new study reveals. Researchers at the School of Medicine demonstrated that in women the variant gene speeds up the breakdown of estrogen and is associated with low density in the bones of the hip.

Diagram and image from an experiment that proved SARS makes a protein in infected cellsAs public health officials in China brace for a potential resurgence in SARS (Sudden Acute Respiratory Syndrome) in connection with Chinese New Year on February 9, researchers at Washington University in St. Louis have published insights into a new protein that could be an important contributor to the SARS virus’ ability to cause disease and death.